Publications by authors named "Jorge Ruiz"

Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into various lineages. They have also the potential to protect themselves against harmful stimuli to maintain their functional integrity. Drug resistance-related transporters such as ABCB1 (P-glycoprotein; P-gp), ABCC1 (MRP1; multidrug resistance-related Protein 1), and LRP (lung resistance protein) may protect MSCs against toxic substances such as chemotherapeutic agents.

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Article Synopsis
  • Aging leads to physiological changes and increased disease vulnerability, culminating in higher mortality rates as individuals get older.
  • Regular physical activity (PA) and exercise can counteract aging effects, improve health span, and reduce the risk of chronic diseases such as heart disease and cancer.
  • Personalized exercise plans, including various forms of training like aerobic and resistance exercises, are essential for maintaining health and functionality in older adults, particularly those with age-related issues.
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Background: Studies have shown that frailty was increased in hospitalized COVID-19 patients. However, it is not clear whether non-severe COVID-19 increases the risk for pre-frailty and frailty development. Our study aimed to determine the risk of developing frailty and pre-frailty in robust veterans who contracted non-severe COVID-19.

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  • The study examined how health insurance affects access to oral health services (OHS) in Peru between 2015 and 2019, particularly for low-income populations facing high treatment costs.
  • It used data from the National Household Survey, analyzing responses from over 4,000 individuals over five years to determine the relationship between health insurance status and OHS usage.
  • Results indicated that consistent health insurance coverage was linked to a higher likelihood of using OHS, suggesting that improving insurance access could enhance oral health care in Peru.*
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Antarctica harbors a microbial diversity still poorly explored and of inestimable biotechnological value. Cold-adapted microorganisms can produce a diverse range of metabolites stable at low temperatures, making these compounds industrially interesting for biotechnological use. The present work investigated the biotechnological potential for antimicrobial and antitumor activity of filamentous fungi and bacteria isolated from marine sediment samples collected at Deception Island, Antarctica.

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  • The study investigated how high neutrophil-to-lymphocyte ratio (NLR) values correlate with inpatient mortality and clinical outcomes in older veterans hospitalized with COVID-19.
  • Researchers analyzed data from 615 hospitalized veterans, finding that higher NLR values were linked to increased rates of inpatient mortality and ICU admissions.
  • The findings suggest that the NLR score can help predict the risk of death in older COVID-19 patients, making it a potentially valuable clinical tool.
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The gastrointestinal tract (GIT) is the target of assorted pathological conditions, and dietary components are known to affect its functionality and health. In previous studies, we observed that reducing sugars induced protein glycoxidation and impaired protein digestibility. To gain further insights into the pathophysiological effects of dietary sugars, rats were provided with a 30% (w/v) fructose water solution for 10 weeks.

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Background: Older populations have suffered the highest rates of SARS-CoV-2 infection and associated complications, including Post-Acute Sequelae of SARS-CoV-2 infection (PASC). Frailty is a geriatric syndrome that often coexists with COVID-19 infection. The vulnerability to stressors caused by multisystemic dysfunction that characterizes frailty may predispose older adults to develop PASC.

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Background: Long-distance migratory birds spend most of their annual cycle in non-breeding areas. During this period birds must meet their daily nutritional needs and acquire additional energy intake to deal with future events of the annual cycle. Therefore, patterns of space use and movement may emerge as an efficient strategy to maintain a trade-off between acquisition and conservation of energy during the non-breeding season.

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a common cause of community-acquired bacterial pneumonia, can cross the respiratory epithelial barrier to cause lethal septicemia and meningitis. pore-forming toxin pneumolysin (PLY) triggers robust neutrophil (PMN) infiltration that promotes bacterial transepithelial migration and disseminated disease in mice. Apical infection of polarized respiratory epithelial monolayers by at a multiplicity of infection (MOI) of 20 resulted in recruitment of PMNs, loss of 50% of the monolayer, and PMN-dependent bacterial translocation.

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Determine the association between frailty and immediate survival of cardiopulmonary resuscitation (CPR) in older Veterans. Secondary outcomes: compare in-hospital mortality, duration of resuscitation efforts, hospital and intensive care unit (ICU) length of stay, neurologic outcomes, and discharge disposition between frail and non-frail Veterans. Retrospective cohort study including Veterans 50 years and older, who were "Full Code" and had in-hospital cardiac arrest between 7/1/2017 and 6/30/2020, at the Miami VAMC.

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royal jelly (RJ) is a well-known remedy in traditional medicine around the world and its versatile effects range from antibacterial to anti-inflammatory properties and pro-regenerative properties. As a glandular product, RJ has been shown to contain a substantial number of extracellular vesicles (EVs), and, in this study, we aimed to investigate the extent of involvement of RJEVs in wound healing-associated effects. Molecular analysis of RJEVs verified the presence of exosomal markers such as CD63 and syntenin, and cargo molecules MRJP1, defensin-1, and jellein-3.

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Resilience theory has taken center stage in tackling the challenge of wetland recovery on a fast-changing planet. Because of waterbirds' enormous dependence on wetlands, their numbers have long been used as surrogates for wetland recovery over time. However, immigration of individuals can mask actual recoveries at a given wetland.

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We assessed spatiotemporal distribution of behavior as a function of the spatial and temporal arrangement of food delivery. Eight food-deprived rats were exposed in an extended experimental chamber to a continuous reinforcement schedule (CRf) or to a fixed interval (FI) 30 s, with three levers contiguous to food dispenser or placed on separate panels. Responses on any of the levers were equally operative on the ongoing schedule.

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Background: Studies have shown that COVID-19 vaccination is effective at preventing infection and death in older populations. However, whether vaccination effectiveness is reduced in patients with frailty is unclear. We aimed to compare vaccine effectiveness against hospitalisation and death after COVID-19 during the surge of the delta (B.

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Background: Frailty, a state of vulnerability to stressors resulting from loss of physiological reserve due to multisystemic dysfunction, is common among hospitalized older adults. Hospital clinicians need objective and practical instruments that identify older adults with frailty. The FI-LAB is based on laboratory values and vital signs and may capture biological changes of frailty that predispose hospitalized older adults to complications.

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Forests that regrow naturally on abandoned fields are important for restoring biodiversity and ecosystem services, but can they also preserve the distinct regional tree floras? Using the floristic composition of 1215 early successional forests (≤20 years) in 75 human-modified landscapes across the Neotropic realm, we identified 14 distinct floristic groups, with a between-group dissimilarity of 0.97. Floristic groups were associated with location, bioregions, soil pH, temperature seasonality, and water availability.

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Background: Frailty, a clinical syndrome characterized by vulnerability to stressors resulting from multisystemic loss of physiological reserve. The use of benzodiazepines in older adults has been associated with confusion, sedation, and cognitive impairment, which in turn may lead to frailty.

Aims: The purpose of this study was to determine the cross-sectional association between frailty and chronic past or current use of benzodiazepine drugs among older US Veterans.

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During germination processes take place that modify the major components of the grain, such is the case of proteins that are hydrolyzed to generate peptides that can lead to the generation of bioactivity. The objective of the present work was to germinate grains of to evaluate the effect on the soluble protein content and the anti-inflammatory activity. The grains were subjected to 10 days of germination at 24 °C and relative humidity of 75%.

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Background: The recent shift to video care has exacerbated disparities in health care access, especially among high-need, high-risk (HNHR) adults. Developing data-driven approaches to improve access to care necessitates a deeper understanding of HNHR adults' attitudes toward telemedicine and technology access.

Objective: This study aims to identify the willingness, access, and ability of HNHR veterans to use telemedicine for health care.

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Background: Conditions encountered en route can dramatically impact the energy that migratory species spend on movement. Migratory birds often manage energetic costs by adjusting their behavior in relation to wind conditions as they fly. Wind-influenced behaviors can offer insight into the relative importance of risk and resistance during migration, but to date, they have only been studied in a limited subset of avian species and flight types.

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