Multichannel Wireless Neurosensing System for battery-free monitoring of neuronal activity.

Electrical activity recordings are critical for evaluating and understanding brain function. We present a novel wireless, implantable, and battery-free device, namely the Wireless Neurosensing System (WiNS), and for the first time, we evaluate multichannel recording capabilities in vivo. For a preliminary evaluation, we performed a benchtop experiment with emulated sinusoidal signals of varying amplitude and frequency, representative of neuronal activity.

Serotype-based evaluation of an optogenetic construct in rat cortical astrocytes.

Optogenetics is a modern technique which has been recently expanded to non-neuronal cell types, e.g., astrocytes, and involves targeted gene delivery of light-sensitive ion channels like Channelrhodopsin-2 (ChR2).

Simultaneous Ca Imaging and Optogenetic Stimulation of Cortical Astrocytes in Adult Murine Brain Slices.

Astrocytes are actively involved in a neuroprotective role in the brain, which includes scavenging reactive oxygen species to minimize tissue damage. They also modulate neuroinflammation and reactive gliosis prevalent in several brain disorders like epilepsy, Alzheimer's, and Parkinson's disease. In animal models, targeted manipulation of astrocytic function via modulation of their calcium (Ca ) oscillations by incorporating light-sensitive cation channels like Channelrhodopsin-2 (ChR2) offers a promising avenue in influencing the long-term progression of these disorders.

A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model.

Cortical spreading depression (SD) is a spreading disruption of ionic homeostasis in the brain during which neurons experience complete and prolonged depolarizations. SD is the basis of migraine aura and is increasingly associated with many other brain pathologies. Here, we study the role of glutamate and NMDA receptor dynamics in the context of an ionic electrodiffusion model.