Pathogenic CCR6+ dendritic cells in the skin lesions of discoid lupus patients: a role for damage-associated molecular patterns.

Background: Discoid lupus erythematosus (DLE) is a cutaneous autoimmune inflammatory disease in which the role of conventional dendritic cells (cDCs) in skin damage has not been evaluated.

Objective: To evaluate the involvement of cDCs in DLE pathogenesis.

Material & Methods: Skin biopsies from 42 patients with DLE were embedded in paraffin or placed in culture.