Interactive Simulation of the ECG: Effects of Cell Types, Distributions, Shapes and Duration.

The shape of the ECG depends on the lead positions but also on the distribution and dispersion of different cell types and their action potential (AP) durations and shapes. We present an interactive JavaScript program that allows fast simulations of the ECG by solving and displaying the dynamics of cardiac cells in tissue using a web browser. We use physiologically accurate ODE models of cardiac cells of different types including SA node, right and left atria, AV node, Purkinje, and right and left ventricular cells with dispersion that accounts for apex-to-base and epi-to-endo variations.

Clinical Outcomes, Health Care Costs and Prognostic Factors for Total Knee Arthroplasty: A Multilevel Analysis of a National Cohort Study Using Administrative Claims Data.

Total knee arthroplasty (TKA) is one of the most frequent orthopaedic surgeries. The purpose of this study was to determine the 30-day postoperative mortality rate, total episode-of-care costs, and prognostic factors associated with these outcomes, for adult patients who underwent TKA in Colombia's contributory health care system. A retrospective cohort study of all adult patients enrolled in Colombia's contributory health system, who underwent TKA between January 1, 2012 and November 30, 2015 was performed.