Publications by authors named "Jorge Palazzi"
Article Synopsis
- Metabolic syndrome (MS) negatively impacts reproductive health in female mice, leading to issues like disrupted estrous cycles and impaired reproductive success.
- In the study, mice on a high-fat diet showed signs of MS, such as insulin resistance and hormonal imbalances, which affected their endometrial health and reproductive outcomes.
- Treatment with metformin improved these reproductive issues by normalizing hormone levels and restoring proper endometrial function, suggesting potential benefits for women with MS seeking to enhance reproductive health.
An Extensive Quality Control and Quality Assurance (QC/QA) Program Significantly Improves Inter-Laboratory Concordance Rates of Flow-Cytometric Minimal Residual Disease Assessment in Acute Lymphoblastic Leukemia: An I-BFM-FLOW-Network Report.
Cancers (Basel)
December 2021
Article Synopsis
- - Monitoring minimal residual disease (MRD) through flow cytometry (FCM) is essential for predicting outcomes in acute lymphoblastic leukemia (ALL), but requires skilled laboratory personnel and ongoing quality checks.
- - The international Berlin-Frankfurt-Münster (I-BFM) consortium created a comprehensive training and quality control program to standardize FCM-MRD practices across multiple reference labs.
- - Key elements of this program include a twinning maturation program, mandatory external quality assessments, regular data trials, and independent survey evaluations, resulting in significantly improved accuracy and consistency in MRD detection in pediatric ALL patients.
Objective The present study compares immune and endocrine parameters between HIV-infected patients who underwent the Immune Reconstitution Inflammatory Syndrome (IRIS-P) during antiretroviral therapy (ART) and HIV-patients who did not undergo the syndrome (non-IRIS-P). Materials and methods Blood samples were obtained from 31 HIV-infected patients (15 IRIS-P and 16 non-IRIS-P) before ART (BT) and 48 ± 2 weeks after treatment initiation (AT). Plasma Interleukin-6 (IL-6) and Interleukin-18 (IL-18) were determined by ELISA.
View Article and Find Full Text PDFBackground: The biological relevance of nuclear ErbB-2/HER2 (NuclErbB-2) presence in breast tumors remains unexplored. In this study we assessed the clinical significance of ErbB-2 nuclear localization in primary invasive breast cancer. The reporting recommendations for tumor marker prognostic studies (REMARK) guidelines were used as reference.
View Article and Find Full Text PDFC57BL/6 mice infected with Trypanosoma cruzi, the causal agent of Chagas' disease, develop severe thymocyte depletion paralleled by an inflammatory syndrome mediated by tumor necrosis factor-alpha (TNF-alpha). The exacerbated inflammatory reaction induces the activation of hypothalamus-pituitary-adrenal (HPA) axis with the consequent release of corticosterone (CT) into the circulation as a protective response. Thymocyte apoptosis has been related to a rise in TNF-alpha and CT levels, and both mediators are increased in T.
View Article and Find Full Text PDFBackground & Aims: Postprandial increases in portal pressure may influence esophageal variceal rupture. The effects of chronic propranolol and octreotide (100 and 200 microg subcutaneously in a single dose) on postprandial hemodynamics were evaluated.
Methods: FIRST STUDY: 36 cirrhotic patients were studied at baseline and 30 and 60 minutes after a standard meal and then treated with propranolol (139 +/- 9 mg/d during 39 +/- 2 days).