Publications by authors named "Jorge Oldan"

Infant ectopic cervical thymus is a relatively uncommon diagnosis and, in many cases, subclinical. If not subclinical, it may present as a palpable swelling or with compressive symptoms (i.e.

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  • * An analysis of the training resources from different companies and organizations revealed that their educational materials vary widely in length (20 to 315 minutes) and content, specifically the number of interpretive tips and pitfalls offered (approximately 12-30).
  • * These differences in training modules highlight the potential for variability in interpretation among healthcare providers, depending on which training they have undergone and the specific radiotracers they utilize.
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Introduction: There is growing interest in the development and application of standardized imaging criteria (SIC), to minimize variability and improve the reproducibility of image interpretation in head and neck squamous cell carcinoma (HNSCC).

Methods: "Squamous cell carcinoma" AND "standardized interpretation criteria" OR "radiographic response assessment" were searched using PubMed and Google Scholar for articles published between 2009 and 2024, returning 56 publications. After abstract review, 18 were selected for further evaluation, and 6 different SICs (i.

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  • Indeterminate renal masses are often discovered incidentally through imaging, and Tc-sestamibi scans can help differentiate between oncocytomas and certain types of renal cell carcinomas, particularly chRCC, which may often be misclassified as false positives.
  • A review of 18 patients with solitary tumors revealed that 72.2% of the tumors remained classified as chRCC, though some were reclassified into different categories, indicating a potential for misinterpretation in imaging.
  • The findings suggest that the false-positive rate for chRCC on renal sestamibi scans may have been exaggerated, highlighting the need for further research to improve non-invasive assessment of indeterminate renal masses.
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Anatomic imaging with contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) has long been the mainstay of renal mass characterization. However, those modalities are often unable to adequately characterize indeterminate, solid, enhancing renal masses - with some exceptions, such as the development of the clear-cell likelihood score on multi-parametric MRI. As such, molecular imaging approaches have gained traction as an alternative to anatomic imaging.

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  • - Endometriosis can lead to issues like infertility, pelvic pain, and painful periods, and prior reports suggested that an 18F-fluoroestradiol (FES) tracer might help detect lesions using PET imaging.
  • - In a study involving 6 patients, FES was administered and then imaged using a specialized PET-MR scanner, with surgical exploration following as the diagnostic standard.
  • - The findings showed that PET was less sensitive than MR for identifying endometriosis lesions, and there was no significant correlation between tracer uptake and pain levels, indicating that FES PET-MR does not add value beyond standard MR imaging.
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Adenoid cystic carcinoma (ACC) of the Bartholin gland is an exceedingly rare neoplasm. A 56-year-old woman with remote ACC resection (plus neoadjuvant chemoradiation and adjuvant chemotherapy) presented to an outside institution with shortness of breath. CT showed bilateral pulmonary nodules and mediastinal lymphadenopathy.

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With the increase in use of GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy, Rybelsus) in the population, nuclear medicine physicians should be aware of the possibility of nondiagnostic FDG PET scans due to these medications, which work partly by increasing insulin secretion. We demonstrate a case where a patient's use of such a medication presumptively led to muscular and myocardial uptake, complicating scan interpretation considerably. Clinicians should be aware of the presence of these drugs and their potential effect on biodistribution in FDG PET.

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  • Prostate cancer (PCa) is the leading form of cancer (excluding skin cancer) in men, and recent advancements in imaging and treatment have improved the diagnosis and therapy options for those affected, particularly for advanced and metastatic cases.
  • Advances in urea-based, small-molecule inhibitors targeting prostate-specific membrane antigen (PSMA) have shown promise in initial staging and detecting recurrent PCa, providing high specificity for identifying pelvic nodal involvement.
  • A specific PSMA-targeted therapy has been linked to improved survival outcomes when used alongside standard treatments for patients with metastatic, castration-resistant PCa, suggesting new opportunities for more effective therapies in the future.
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Renal cell carcinoma (RCC) and urothelial carcinoma (UC) are two of the most common genitourinary malignancies. 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) can play an important role in the evaluation of patients with RCC and UC. In addition to the clinical utility of 18F-FDG PET to evaluate for metastatic RCC or UC, the shift in molecular imaging to focus on specific ligand-receptor interactions should provide novel diagnostic and therapeutic opportunities in genitourinary malignancies.

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Purpose: Endometriosis is an estrogen-dependent disorder of menstruating primates where tissues similar to the inner lining of the uterus exist "ectopically" outside of the uterus. The ectopic endometrium, like the endometrium within the uterus, expresses estrogen receptors (ER) and progesterone receptors (PR) and undergoes hormone-dependent cell proliferation and bleeding each menstrual cycle. The goal of this study was to conduct abdominopelvic positron emission tomography (PET) scans with computed tomography (CT) imaging of rhesus macaques (Macaca mulatta) using radiotracers that target ER and PR [16α-[F]fluoroestradiol (FES) and 12-[F]fluoro-furanyl-nor-progesterone (FFNP)] in individuals with and without endometriosis.

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This study aimed to assess the accuracy of intraprostatic tumor volume measurements on prostate-specific membrane antigen-targeted F-DCFPyL PET/CT made with various segmentation methods. An accurate understanding of tumor volumes versus segmentation techniques is critical for therapy planning, such as radiation dose volume determination and response assessment. Twenty-five men with clinically localized, high-risk prostate cancer were imaged with F-DCFPyL PET/CT before radical prostatectomy.

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The discovery and clinical development of radiolabeled small-molecule ligands targeting prostate-specific membrane antigen (PSMA) has had a profound influence on the field of nuclear medicine. Such agents have been successfully deployed for both imaging and therapeutic applications. In particular, PSMA radioligand therapy (PRLT) has been shown to be a life-prolonging therapy for men with metastatic, castration-resistant prostate cancer and has also brought nuclear medicine physicians and nuclear radiologists into the forefront of direct patient care.

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Purpose: Few investigations have examined the uptake of radiotracers that target the prominent sex-steroid receptors in the uterus across the menstrual cycle and with disease state. We aimed to determine if uptake of the radiotracers that target estrogen and progesterone receptors (ER and PR) differ with the presence of endometriosis and/or across the menstrual cycle. We performed PET and computed tomography (CT) imaging procedures on rhesus macaques () using 16α-[18F]fluoroestradiol (FES) and 21-[18F]fluoro-furanyl-nor-progesterone (FFNP) in individuals with and without endometriosis in the proliferative and secretory phases of the menstrual cycle.

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  • [F]DCFPyL is used for imaging prostate cancer patients with biochemically recurrent prostate cancer (BRPCa), and this meta-analysis assesses its detection efficiency across various studies, including the key CONDOR trial.
  • The study analyzed data from 17 articles involving 2,252 patients, finding that the overall detection rate of [F]DCFPyL is 0.73, which is lower than previous estimates, especially in relation to serum PSA levels.
  • The results indicate that detection efficiency is better in patients with higher PSA levels but remains unaffected by the rate of PSA doubling time; these findings suggest that stricter study criteria may have influenced the lowered detection rates over time.
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Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine one is essential. We immunohistochemically stained tissues along the nevus-to-MM progression pathway for tryptophan-metabolizing enzymes (TMEs; TPH1, TPH2, TDO2, IDO1) and the tryptophan transporter, LAT1.

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Introduction: Peer learning and near-peer teaching have been described in many specialties, less so in Radiology. We present near-peer teaching whereby residents present a series of didactic sessions at the course outset in the form of "symposia" and perform a scholarly activity in the form of teaching. We aim to demonstrate how near-peer teaching in symposia front-loaded within an introductory radiology course can improve medical student satisfaction.

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  • There is currently no agreement among major medical organizations on the fixed dosage of radioactive iodine (RAI) for treating Graves' disease, prompting this study to evaluate a standard dose of 15 mCi ±10%.
  • A retrospective review of patient charts from 2014 to 2020 identified 67 cases of hyperthyroidism due to Graves' disease, categorizing the outcomes based on the 15 mCi ±10% dosage effectiveness.
  • Results showed that a high percentage (89.55%) of patients became hypothyroid after treatment, suggesting that a standardized low dose could simplify treatment protocols and eliminate the need for complex calculations in determining thyroid weight for RAI treatments.
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While the presence of incidental breast and lung masses on cardiac scans is well known, renal masses are often incidentally discovered as well on cardiac examinations, some of which are malignant. We searched the electronic medical record system over the past 18 years, since the system was installed, for patients with a cardiac rubidium-82 (Rb) rubidium PET/CT or technetium-99m (Tc) sestamibi SPECT/CT performed within 1 year of a renal-protocol CT or MR. Each PET/CT or SPECT/CT was examined for presence of a renal lesion on the attenuation-correction CT images.

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We present a case of abnormal findings on a Tc99m-Sestamibi parathyroid scan, post COVID-19 vaccination. The patient is a 48-year-old female presenting for evaluation of hyperparathyroidism who received the mRNA-1273 Moderna (ModernaTX, Inc.) vaccine seven days prior to the scan.

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 Chest tumors are often found incidentally on cardiac scans; we aimed to describe the findings of rubidium (Rb) in incidentally discovered extracardiac tumors.  We reviewed a database of cardiac Rb scans performed over a period of 11 years and identified those with a previously unsuspected malignancy seen on the plane of section. We then measured maximum standard uptake value for each of the tumors, as well as background lung, liver, mediastinum, and body wall.

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Objective: The aim of this study was to determine whether quantitative methods could aid in the evaluation of post-treatment head and neck scans, particularly taking human papillomavirus status into account.

Methods: Clinical readings of positron emission tomography/computed tomography scans as well as standardized uptake value (SUV)max (and other metrics) of nodes visible on PET conducted on a total of 172 patients with head and neck squamous cell cancer were examined. Locoregional recurrence at 2 years was assessed.

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Our group has recently demonstrated that chimeric antigen receptor T-cell therapy targeting the CD30 antigen (CD30.CAR-T) is highly effective in patients with relapsed and refractory (r/r) classical Hodgkin lymphoma (cHL). Despite high rates of clinical response, relapses and progression were observed in a subset of patients.

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Breast imaging, with its unique patient-facing, multimodality, and multidisciplinary workflow, offers opportunities to engage medical students enrolled in a general radiology rotation and to highlight the role of the radiologist in patient care. At a time when breast radiologists face unprecedented challenges in delivering safe and efficient imaging services, however, accommodating larger numbers of medical students can overwhelm reading rooms, dilute meaningful learning experiences for the student, and place further demands on faculty. In order to meet the students' and clinician educators' needs, Neher's one-minute preceptor teaching strategy is used to create a high-yield learning environment in a short amount of time.

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