Validation of a paper chromatographic methodology as an alternative for determination of the radiochemical purity of Na18F.

Unlabelled: The aim of the present work was to validate a paper chromatography system as an alternative way to determine the radiochemical purity of Na(18)F.

Methods: The evaluated parameters were specificity, limit of quantification, measurement interval, linearity, precision, accuracy, and robustness.

Results: The proposed method proved to be linear (P > 0.

Radioactive treatment of a murine melanoma using a (32)P-patch.

Objective: To evaluate the therapeutic effects of a (32)P-patch in the treatment of a murine melanoma.

Materials And Methods: Thirty male C57BL6 mice were divided into two groups: treated and control. Superficial tumors were induced in both groups by injecting B16F1 melanoma at about 10 cells/mouse subcutaneously.

Bioevaluation of 32P patch designed for the treatment of skin diseases.

Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases.

Materials And Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied.

Quality control validation for exogenous natural surfactant labeled with 99mTc.

Objective: Exogenous natural surfactant (ENS) labeled with 99mTc shows an elevated lung specificity allowing the acquisition of high-quality images for ventilation scintigraphy.

Methods: The methods for 99mTc-ENS quality control (physical properties, pH determination, radiochemical studies, and biologic studies) were evaluated and validated.

Results: The physical properties of the nonradioactive precursor and of the radiopharmaceutical were analyzed as general descriptors of the product.

Effects of radiosynovectomy with p-32 colloid therapy in hemophilia and rheumatoid arthritis.

Aim: The aim of this study was to assess the effects of treatment with our locally produced P-32 colloidal suspension on knee synovitic inflammations of hemophilic and rheumatoid arthritis (RA) patients, as well as to compare results with chemical synovectomy or corticoid intra-articular injections and evaluate the cost-benefit ratio.

Materials And Methods: Thirty-six hemophilic male patients, 4-28 years of age and sent by the Hemophilic Foundation (Buenos Aires, Argentina), were enrolled for knee radiosynovectomy (RS) with P-32 colloid (26 patients), or the antibiotic rifampicin with the cooperation of orthopaedists (10 patients). Parents' informed consent was obtained.