Publications by authors named "Jorge Mendieta-Calle"
Article Synopsis
- - Natural oak toxicity occurs when ruminants like cattle consume parts of oak trees, leading to severe health issues due to the breakdown of plant tannins by gut microbes and enzymes.
- - Symptoms of acute oak toxicity resemble those of renal disease, specifically acute tubular injury, which can be fatal.
- - A study of three beef calves in Colorado revealed significant kidney damage and unique microscopic features of oak-induced toxicity, highlighting previously undocumented effects on renal tissues and blood vessels.
Objectives: To determine the extent that zoledronate (ZOL) dose and duration is associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ) prevalence in rice rats with generalized periodontitis (PD), characterize structural and tissue-level features of BRONJ-like lesions in this model, and examine the specific anti-resorptive role of ZOL in BRONJ.
Materials And Methods: Rice rats (n = 228) consumed high sucrose-casein diet to enhance generalized PD. Groups of rats received 0, 8, 20, 50 or 125 µg/kg IV ZOL/4 weeks encompassing osteoporosis and oncology ZOL doses.
Rice rats () are an unconventional laboratory species that has been used to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional procedures that require anesthesia, including oral procedures, are sometimes necessary in preclinical settings. The use of anesthetics including isoflurane and ketamine combined with α2-adrenoreceptor agonists, such as dexmedetomidine and xylazine, is well-established for laboratory rodents.
View Article and Find Full Text PDFThe parasitic nematode Angiostrongylus cantonensis is a major cause of eosinophilic meningitis in humans, and has been documented in other incidental hosts such as birds, horses, dogs and non-human primates. It is endemic in Hawaii, and there have been sporadic reports in the southern continental United States. This parasite uses rats as definitive hosts and snails as intermediate hosts.
View Article and Find Full Text PDFArticle Synopsis
- - Marsh rice rats (Oryzomys palustris) are used to study periodontitis, and researchers examined the occurrence of food-impaction lesions (FIL) in these rats fed standard rodent chow from weaning until 34 weeks of age.
- - The study found that the prevalence of FIL increased with age, showing up in almost 82% of rats by 28 weeks, primarily on the maxillary palatal surfaces between certain molars, and was absent in the mandible.
- - Histological analysis revealed that FIL ranged from mild gingivitis to more severe lesions, indicating these FIL can serve as a model for exploring localized maxillary periodontitis, especially when the rats are given standard chow