Publications by authors named "Jorge Mejia-Barajas"
Membrane fatty acid composition has an important role in yeast stress resistance, particularly in temperature tolerance. Most studies investigating temperature and membrane fatty acids use the yeast Saccharomyces cerevisiae without considering other yeasts, such as Kluyveromyces marxianus, which has physiological differences and industrial advantages with respect to S. cerevisiae.
View Article and Find Full Text PDFAvocado oil induces long-term alleviation of oxidative damage in kidney mitochondria from type 2 diabetic rats by improving glutathione status.
J Bioenerg Biomembr
April 2017
Article Synopsis
- Hyperglycemia and excessive ROS production are major contributors to diabetic nephropathy, leading researchers to explore ways to lower glucose levels and improve antioxidant status.
- Previous studies indicated that avocado oil positively affects glutathione levels in diabetic rats' livers and brains, but long-term effects were unclear due to high mortality in other models.
- A year-long study using type 2 diabetic Goto-Kakizaki rats showed that avocado oil reduced blood sugar levels, decreased oxidative stress, improved glutathione status, and increased oleic acid in kidney mitochondria, highlighting its potential benefits.
Yeasts capable of growing and surviving at high temperatures are regarded as thermotolerant. For appropriate functioning of cellular processes and cell survival, the maintenance of an optimal redox state is critical of reducing and oxidizing species. We studied mitochondrial functions of the thermotolerant Kluyveromyces marxianus SLP1 and the mesophilic OFF1 yeasts, through the evaluation of its mitochondrial membrane potential (ΔΨ), ATPase activity, electron transport chain (ETC) activities, alternative oxidase activity, lipid peroxidation.
View Article and Find Full Text PDFStress tolerance is a key attribute that must be considered when using yeast cells for industrial applications. High temperature is one factor that can cause stress in yeast. High environmental temperature in particular may exert a natural selection pressure to evolve yeasts into thermotolerant strains.
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