Publications by authors named "Jorge M Iravedra Garcia"
A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum depends on the cognitive requirements of a task.
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- The prefrontal cortex (PFC) helps process information to guide decision-making, especially when faced with competing motivations like seeking food versus avoiding danger.
- In an experiment with rats, researchers found that specific brain regions (PL PFC, BLA, and VS) are crucial for avoiding a footshock while trying to access a food reward.
- Using techniques to manipulate the activity of neurons in these regions, they discovered that stimulating different pathways affected the rats' decision to avoid the shock, indicating complex interactions between the PFC, amygdala, and striatum in decision-making under conflict.