Publications by authors named "Jorge Luiz M Sampaio"
Daptomycin Resistance and Tolerance Due to Loss of Function in Staphylococcus aureus and .
Antimicrob Agents Chemother
January 2019
Article Synopsis
- Daptomycin is a last-resort antibiotic for treating multidrug-resistant infections, but resistance to it has emerged, highlighting a critical concern.
- Researchers identified specific mutants with higher resistance from a library of genetic variations in a bacterial strain, pinpointing two key genes linked to this increased resistance.
- The study reveals that these genetic alterations not only confer resistance to daptomycin but also enhance tolerance to other antibiotics and substances, suggesting new targets for understanding and combating antimicrobial resistance.
We investigated the occurrence and phenotypic and genotypic characteristics of erythromycin-resistant Streptococcus pneumoniae strains isolated in three major states in Brazil, from 1990 to 1999. Of the 931 pneumococcal strains evaluated, 40 (4.3%) were erythromycin-resistant (Ery-R).
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