Publications by authors named "Jorge Lindo"
Health Status and COVID-19 Epidemiology in an Inland Region of Portugal: A Retrospective Study.
Int J Environ Res Public Health
August 2024
Multiple factors, from socioeconomic development to genetic background, can affect the regional impact of some diseases, and this has also been seen during the COVID-19 pandemic. The objective of this retrospective study was to characterize a population in the interior of Portugal regarding health status and COVID-19 epidemiology. Between October 2021 and January 2023, 1553 subjects residing in Beira Baixa, Portugal, were included.
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- SARS-CoV-2 infection severity varies based on the body’s inflammatory response, influenced by purinergic receptors: A2A receptors are anti-inflammatory, while P2X7 receptors promote inflammation.
- This study focused on the genetic variations (SNPs) of two receptors, ADORA2A and P2RX7, to determine their impact on COVID-19 severity among 55 individuals with different infection levels.
- Results showed that the P2RX7 SNP genotype (specifically the TT genotype) was linked to more severe COVID-19 cases, particularly in individuals with multiple health conditions, while the ADORA2A SNP did not show a significant association with infection severity.
Group A Streptococcus (GAS) is one of the most important agents of oropharyngeal infection. To avoid unnecessary antibiotic prescription, it is recommended the confirmation of GAS infection in pharyngeal swabs using culture or rapid antigen detection test (RADT). This study aimed to retrospectively analyse the incidence of GAS oropharyngeal infection, detected by RADT, in a paediatric population in the Centre of Portugal.
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