Zerumbone disrupts mixed biofilms of and on acrylic resin.

The efficacy of Zerumbone (ZER) against mixed biofilms of fluconazole-resistant (ATCC 96901) and (UA159) was evaluated. Biofilms were cultivated on acrylic resin specimens for 48 h, with alternating supplementation of glucose and sucrose. ZER's ability to inhibit biofilm formation (pre-treatment) and eradicate mature biofilms (post-treatment) was assessed.

Tear film stability in children: Age and sex associations explored through non-invasive tear break-up time.

Purpose: The stability of the tear film is crucial for maintaining good ocular health. Its assessment provides valuable insights into paediatric eye conditions. This study investigates the stability of the tear film in children and its association with predictive factors such as age and sex, for a better understanding of tear film dynamics in a paediatric population.

Comparative analysis of visual and cognitive performance in esports athletes and soccer players.

Clinical Relevance: Assessing visual and cognitive performance in athletes is important for optimising training strategies and preventing visual strain in both esports and traditional sports.

Background: This study compared visual acuity, refractive error, binocular functions, and cognitive perception measures between esports and soccer players to optimise visual performance strategies.

Methods: Twenty-eight male esports athletes and 38 male soccer players were assessed.

Clinicopathological, Prognostic and Molecular Profile of Salivary Gland Intraductal Carcinoma: A Systematic Review.

Purpose: This study aimed to conduct a systematic review summarizing the clinicopathological, prognostic, and molecular features of salivary gland intraductal carcinoma (SGIC).

Methods: This study followed the PRISMA 2020 guidelines and was registered in the PROSPERO database. It included case reports, case series studies, and cohort studies of SGIC indexed in the PubMed, Web of Science, Scopus, and Embase databases published between 1983 and 2024.

fractions decrease planktonic cells and biofilms of and .

Extracts of species have been shown to reduce biofilms, demonstrating their antimicrobial effects. The extracts can be fractionated to optimize their potential. In this study, we evaluated the antimicrobial activity of fractions against planktonic cells and biofilms of and .

A Rare Encounter of Postoperative Abscess Not Linked to Staple Line in Sleeve Gastrectomy: A Case Report and Literature Review.

Sleeve gastrectomy is a common bariatric procedure known for its safety and effectiveness, but postoperative complications like abscess formation, though rare, can occur. We report the case of a 37-year-old female who presented with atypical abdominal pain following a sleeve gastrectomy. Imaging revealed an abscess located away from the staple line.

Comparison of the PlusoptiX A16 and vision screener V100.

Clinical Relevance: This study compares a novel photoscreening device with a previously validated one in a school-age population. It highlights a tendency of the new device to underestimate myopic spherical equivalent and overestimate hyperopic cases.

Purpose: To compare the PlusoptiX A16 and Vision Screener V100 photoscreeners in a study population of school-age children.

Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study.

Resting-state functional connectivity (FC) MRI is sensitive to brain changes in Alzheimer's disease in preclinical stages, however studies in persons with subjective cognitive decline (SCD) have reported conflicting findings, and no study is available at 7T MRI. In this study, we investigated FC alterations in sixty-six participants recruited at the Geneva Memory Center (24 controls, 14 SCD, 28 cognitively impaired [CI]). Participants were classified as SCD if they reported cognitive complaints without objective cognitive deficits, and underwent 7T fMRI to assess FC in canonical brain networks and their association with cognitive/clinical features.

Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles.

This study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy. The nanoparticles were designed with a diameter between 20 and 50 nm to optimize cellular uptake and avoid rapid clearance from the bloodstream. The synthesis method involved modifying a previously reported technique to reduce particle size.

Estimating the burden of care for oral potentially malignant disorders and oral cancer in Brazilian dental practice.

Background: Oral cancer (OC) and oral potentially malignant disorders (OPMD) pose significant challenges to public health in Brazil. This study aimed to estimate the prevalence of oral cancer (OC) and oral potentially malignant disorders (OPMD) among patients who would be treated by Brazilian dentists during their careers.

Material And Methods: Data on the number of dentists in Brazil were extracted from the 2022 census data, while incidence rates for OC cases were sourced from the Brazilian National Cancer Institute (INCA).

Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma.

Ethnopharmacological Relevance: Glioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options.

Intelligent systems in healthcare: A systematic survey of explainable user interfaces.

With radiology shortages affecting over half of the global population, the potential of artificial intelligence to revolutionize medical diagnosis and treatment is ever more important. However, lacking trust from medical professionals hinders the widespread adoption of AI models in health sciences. Explainable AI (XAI) aims to increase trust and understanding of black box models by identifying biases and providing transparent explanations.

Uncommon Etiologies of Acute Abdominal Pain: A Case Report on Omental Infarction.

Omental infarction is an uncommon cause of abdominal pain. The condition is often misdiagnosed due to its clinical similarity to more common abdominal pathologies like appendicitis and cholecystitis. This report presents the case of a 57-year-old female with a one-week history of left-sided abdominal pain, initially aggravated by eating and defecation.

The antimicrobial activity of an antiseptic soap against Candida Albicans and Streptococcus Mutans single and dual-species biofilms on denture base and reline acrylic resins.

To evaluate the effect of antiseptic soap on single and dual-species biofilms of Candida albicans and Streptococcus mutans on denture base and reline resins. Samples of the resins were distributed into groups (n = 9) according to the prevention or disinfection protocols. In the prevention protocol, samples were immersed in the solutions (Lifebuoy, 0.

Intraoral Salivary Gland Cystadenomas: A Case Series Study and Literature Review.

Background: Salivary gland cystadenoma (SGCA) is a rare benign tumor that predominantly occurs in the parotid gland. SGCAs affecting the minor salivary glands are uncommon and often resemble, clinically and histopathologically, other salivary gland lesions.

Methods: This study aimed to describe a series of four cases of SGCA affecting intraoral sites and performed a literature review of well-reported SGCA published in the English-language literature.

Effect of antihypertensive agents on sleep apnea and ambulatory blood pressure in patients with hypertension: A randomized controlled trial.

Background: Obstructive sleep apnea (OSA) and hypertension are common conditions that may be linked through sympathetic activation and water retention. We hypothesized that diuretics, which reduce the body water content, may be more effective than amlodipine, a blood pressure (BP)-lowering agent implicated with edema, in controlling OSA in patients with hypertension. We also aimed to compare the effects of these treatments on ambulatory blood pressure monitoring (ABPM).

() expression is activated under oxidative stress conditions acting as a metabolic repressor of .

Aspergilli comprise a diversity of species that have been extensively studied due to their catabolic diversity, biotechnological and ecological value, and pathogenicity. An impressive level of structural and functional conservation has been shown for aspergilli, regardless of many (yet) cryptic genomic elements. We have hypothesized the existence of conserved genes responsive to stress in aspergilli.

Fungi: friends or foes-an outreach science initiative for the collection of airborne fungal spores by high school students.

Fungi mostly reproduce through spores that are adapted for airborne dispersal; hence, fungal spores (and fungi) are found virtually everywhere. Fungi can be "friends or foes." Our friends include fungi used in the food and biotech industries, fungi that contribute to the cycling of carbon and nutrients, and those involved in the decontamination of polluted soils and/or water, to mention just a few examples.

The Arrow Macambira (Encholirium spectabile: Bromeliaceae) as an Important Habitat for the Arthropod Fauna in Rocky Outcrops of the Brazilian Semi-Arid Region.

Bromeliads play a vital role in preserving biodiversity in the Neotropical region. To understand their impact on arthropod diversity in Brazil's semi-arid region, we studied the rupicolous bromeliad Encholirium spectabile. From 2011 to 2018, we observed the arthropod fauna in E.

Semi-arid's Unsung Heroes: Hymenoptera and the Vital Ecosystem Services Enabled by Encholirium spectabile, a Rupicolous Bromeliad in the Brazilian Semi-arid Region.

The concept of Ecosystem Services (ES) recognizes the importance of natural ecosystems in supporting human well-being. Hymenoptera, a diverse group of insects including ants, bees, and wasps, play crucial roles in providing ESs. Despite their significance, the provision of ESs by Hymenoptera is often undervalued, leading to ecosystem degradation and loss of important services.

Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hematological Tumors.

The role of metalloproteinases (MMPs) in hematological malignancies, like acute myeloid leukemia (AML), myelodysplastic neoplasms (MDS), and multiple myeloma (MM), is well-documented, and these pathologies remain with poor outcomes despite treatment advancements. In this study, we investigated the effects of batimastat (BB-94), an MMP inhibitor (MMPi), in single-administration and daily administration schemes in AML, MDS, and MM cell lines. We used four hematologic neoplasia cell lines: the HL-60 and NB-4 cells as AML models, the F36-P cells as an MDS model, and the H929 cells as a model of MM.

Health promotion of Street Clinic workers: convergent care research.

Objective: To develop a health promotion action for Street Clinic workers.

Method: Qualitative research which used the Convergent Care Research methodology. The data collection was conducted through participant observation and convergence groups, from May to October 2021, with 39 workers from six teams of the Street Clinic.

c-di-AMP determines the hierarchical organization of bacterial RCK proteins.

In bacteria, intracellular K is involved in the regulation of membrane potential, cytosolic pH, and cell turgor as well as in spore germination, environmental adaptation, cell-to-cell communication in biofilms, antibiotic sensitivity, and infectivity. The second messenger cyclic-di-AMP (c-di-AMP) has a central role in modulating the intracellular K concentration in many bacterial species, controlling transcription and function of K channels and transporters. However, our understanding of how this regulatory network responds to c-di-AMP remains poor.

CONSTIPATION SCORING SYSTEM VALIDATED FOR THE PORTUGUESE LANGUAGE (ÍNDICE DE GRAVIDADE DA CONSTIPAÇÃO INTESTINAL): IS IT RELIABLE IN ASSESSING THE SEVERITY OF INTESTINAL CHRONIC CONSTIPATION IN OUR POPULATION?

Background: There is a lack of valid and specific tools to measure chronic constipation severity in Brazil.

Aims: To validate the Constipation Scoring System for Brazilian spoken Portuguese.

Methods: Translation, cultural adaptation, and validation itself (reliability and convergent and divergent validation).

In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation.

Reversine is a purine derivative that has been investigated with regard to its biological effects, such as its anticancer properties and, mostly, its ability to induce the dedifferentiation of adult cells, increasing their plasticity. The obtained dedifferentiated cells have a high potential for use in regenerative procedures, such as regenerative dentistry (RD). Instead of replacing the lost or damaged oral tissues with synthetic materials, RD uses stem cells combined with matrices and an appropriate microenvironment to achieve tissue regeneration.