Publications by authors named "Jorge Hernandez Campano"
Article Synopsis
- - The study highlights that while excitatory amino acids like glutamate and aspartate are known to contribute to brain damage during ischemia, the impact of non-excitatory amino acids (like L-alanine and glycine) is not well understood, despite their potential role in worsening brain injuries.
- - Findings show that exposure to a combination of specific non-excitatory amino acids during transient hypoxia can cause irreversible neuronal damage, highlighting a new aspect of brain injury that needs further exploration.
- - The researchers suggest that the swelling of astrocytes due to these amino acids might activate certain channels that release excitotoxins, leading to further neuron damage, indicating that these mechanisms could be important for developing new treatments for conditions
The present work, using chromaffin cells of bovine adrenal medullae (BCCs), aims to describe what type of ionic current alterations induced by lead (Pb) underlies its effects reported on synaptic transmission. We observed that the acute application of Pb lead to a drastic depression of neurotransmitters release in a concentration-dependent manner when the cells were stimulated with both K or acetylcholine, with an IC of 119,57 μM and of 5,19 μM, respectively. This effect was fully recovered after washout.
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