Publications by authors named "Jorge H Grilo"
Pharmaceuticals (Basel)
August 2023
Article Synopsis
- Cancer is a complicated disease influenced by various factors and involves multiple metabolic pathways, including the ubiquitin-proteasome system, which is crucial for protein degradation in cells.
- Current proteasome inhibitors used in treatment face challenges like therapy resistance and severe side effects, highlighting the need for new alternatives.
- A study was conducted to find new proteasome inhibitors, leading to the identification of a promising compound (JHG58) that shows strong protective activity and induces cancer cell death, making it a candidate for further development.
