Publications by authors named "Jorge Gonzalez-Rico"

Cellular spheroids have been described as an appropriate culture system to restore human follicle dermal papilla cells (hFDPc) intrinsic properties; however, they show a low and variable efficiency to promote complete hair follicle formation in in vivo experiments. In this work, a conscientious analysis revealed a 25% cell viability in the surface of the dermal papilla spheroid (DPS) for all culture conditions, questioning whether it is an appropriate culture system for hFDPc. To overcome this problem, we propose the use of human blood plasma for the generation of fibrin microgels (FM) with encapsulated hFDPc to restore its inductive signature, either in the presence or in the absence of blood platelets.

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Cell spheroids have recently emerged as an effective tool to recapitulate native microenvironments of living organisms in anscenario, increasing the reliability of the results obtained and broadening their applications in regenerative medicine, cancer research, disease modeling and drug screening. In this study the generation of spheroids containing primary human dermal fibroblasts was approached using the two-widely employed methods: hanging-drop and U-shape low adhesion plate (LA-plate). Moreover, extrusion-based three-dimensional (3D) bioprinting was introduced to achieve a standardized and scalable production of cell spheroids, decreasing considerably the possibilities of human error.

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Synopsis of recent research by authors named "Jorge Gonzalez-Rico"

  • - Jorge Gonzalez-Rico's recent research focuses on innovative methodologies for enhancing the cultivation and application of human dermal cells in regenerative medicine, particularly hair follicle regeneration and fibroblast functionality.
  • - In his 2024 article, Gonzalez-Rico investigates the effectiveness of fibrin microgels for encapsulating human dermal papilla cells, noting challenges in previous culture systems that affect cell viability and subsequent hair follicle formation.
  • - His earlier work, published in 2022, evaluates various methodologies for creating spheroids from primary human dermal fibroblasts, emphasizing the potential of 3D bioprinting technology to improve consistency and scalability in cell spheroid production for research applications.

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