Publications by authors named "Jorge Garcia Morato"
Trans-activation response DNA binding protein of 43 kDa (TDP-43) regulates a great variety of cellular processes in the nucleus and cytosol. In addition, a defined subset of neurodegenerative diseases is characterized by nuclear depletion of TDP-43 as well as cytosolic mislocalization and aggregation. To perform its diverse functions TDP-43 can associate with different ribonucleoprotein complexes.
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- TDP-43 is a protein linked to diseases like ALS and frontotemporal lobar degeneration, playing a key role in RNA processing and forming harmful aggregates.
- Research showed that acetylation at specific lysine positions (K84 and K136) negatively impacts TDP-43's nuclear import and RNA binding, leading to its phase separation and aggregation.
- The study highlighted that sirtuin-1 can deacetylate K136-acetylated TDP-43, potentially reducing its aggregation, which hints at possible regulatory pathways for TDP-43-related diseases.