NeuropsychBrainAge: A biomarker for conversion from mild cognitive impairment to Alzheimer's disease.

Introduction: BrainAge models based on neuroimaging data have diagnostic classification power but have replicability issues due to site and patient variability. BrainAge models trained on neuropsychological tests could help distinguish stable mild cognitive impairment (sMCI) from progressive MCI (pMCI) to Alzheimer's disease (AD).

Methods: A linear regressor BrainAge model was trained on healthy controls using neuropsychological tests and neuroimaging features separately.