Publications by authors named "Jorge Gabriel Rossi"
An association of deletions in the IKZF1 gene (IKZF1del) with poor prognosis in acute lymphoblastic leukemia (ALL) has been demonstrated. Additional deletions in other genes (IKZF1plus) define different IKZF1del subsets. We analyzed the influence of IKZF1del and/or IKZF1plus in the survival of children with ALL.
View Article and Find Full Text PDFSeveral conventions have been established in order to define and characterize Mixed Phenotype Acute Leukemia (MPAL). However, megakaryocytic markers have not been included in the definition of MPAL neither in the European Group for the Immunological Characterization of Leukemias (EGIL) proposal nor in any of the WHO Classification of Tumors issues. We report four pediatric acute leukemia (AL) cases (prevalence: 0.
View Article and Find Full Text PDFArticle Synopsis
- A study of 233 children with ambiguous lineage leukemia (ALAL) aimed to define treatment strategies, as previous definitions had lacked clear therapy recommendations.
- Results showed that acute lymphoblastic leukemia (ALL)-type treatments led to a significantly higher five-year event-free survival (EFS) rate (80%) compared to acute myeloid leukemia (AML)-type treatments (36%) and combined types (50%).
- The findings recommend using ALL-type treatment for most pediatric ALAL patients, particularly those with CD19 leukemia, while AML-type treatment is advised for a minority, and transplantation shows no overall benefit except for certain poorly responding patients.