Publications by authors named "Jorge Fernandez Perez"
Article Synopsis
- Pathogenic bacteria, like Streptococcus pyogenes, need to acquire iron for growth, making their metal import systems potential targets for new antibiotics.
- S. pyogenes uses the FtsABCD iron uptake system to transport iron from hydroxamate siderophores, despite not being able to produce these compounds itself.
- Research showed that the protein FtsB can bind various siderophores (like ferrichrome and ferrioxamine) with high affinity, indicating S. pyogenes can exploit these other microorganisms' iron sources through specific interactions.
CD40 is a member of the tumor necrosis factor receptor superfamily, and it is widely expressed on immune and non-immune cell types. The interaction between CD40 and the CD40 ligand (CD40L) plays an essential function in signaling, and the CD40/CD40L complex works as an immune checkpoint molecule. CD40 has become a therapeutic target, and a variety of agonistic/antagonistic anti-CD40 monoclonal antibodies (mAbs) have been developed.
View Article and Find Full Text PDFRecent years have seen an uptick in the use of computational applications in antibody engineering. These tools have enhanced our ability to predict interactions with antigens and immunogenicity, facilitate humanization, and serve other critical functions. However, several studies highlight the concern of potential trade-offs between antibody affinity and stability in antibody engineering.
View Article and Find Full Text PDFSurface plasmon resonance (SPR) is widely used for antigen-antibody interaction kinetics analysis. However, it has not been used in the screening phase because of the low throughput of measurement and analysis. Herein, we proposed a high-throughput SPR analysis system named "BreviA" using the Brevibacillus expression system.
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