Publications by authors named "Jorge E Diaz"
Article Synopsis
- Expression of Caveolin-1 (CAV1) is complex; it promotes aggressive behaviors in metastatic cancer cells but acts as a tumor suppressor in early cancer stages, where its expression is often reduced due to epigenetic factors.
- Researchers aimed to find ways to reverse the suppression of CAV1 to understand its impact on cancer cell migration and metastasis, especially in light of anti-cancer drugs often being available in non-lethal amounts during treatment.
- Their findings showed that low CAV1 levels in colon and breast cancer cells could be increased with a specific drug (5'-azacytidine) and also through temporary exposure to cancer drugs, leading to enhanced migration and invasion capabilities without necessarily developing drug resistance.
