Lethal Violence and Migration in Mexico: An Analysis of Internal and International Moves.

We analyze the effect of homicide in Mexico on patterns and processes of internal and international migration. Linking municipal-level homicide rates from 1990 through 2018 with data from the Mexican Migration Project, we estimate a series of multinomial discrete time event history models to assess the effect that exposure to lethal violence has on the likelihood of migration within Mexico and to the United States without documents. Statistical estimates indicate that the homicide rate negatively predicts the likelihood of taking a first undocumented trip to the United States but positively predicts the likelihood of taking a first trip within Mexico.

Evolution of the Mexico-U.S. Migration System: Insights from the Mexican Migration Project.

Since 1987 the Mexican Migration Project has collected and disseminated representative survey data on documented and undocumented migration to the United States. The MMP currently includes surveys of 161 communities, which together contain data on 27,113 households and 169,945 individuals, 26,446 of whom have U.S.

Debacles on the Border: Five Decades of Fact-Free Immigration Policy.

Since 1987 the Mexican Migration Project (MMP) has compiled extensive data on the characteristics and behavior of documented and undocumented migrants to the United States and made them publicly available to users to test theories of international migration and evaluate U.S. immigration and border policies.

Why Border Enforcement Backfired.

In this article we undertake a systematic analysis of why border enforcement backfired as a strategy of immigration control in the United States. We argue theoretically that border enforcement emerged as a policy response to a moral panic about the perceived threat of Latino immigration to the United States propounded by self-interested bureaucrats, politicians, and pundits who sought to mobilize political and material resources for their own benefit. The end result was a self-perpetuating cycle of rising enforcement and increased apprehensions that resulted in the militarization of the border in a way that was disconnected from the actual size of the undocumented flow.

Border Enforcement and Return Migration by Documented and Undocumented Mexicans.

Using data from the Mexican Migration Project we compute probabilities of departure and return for first and later trips to the United States in both documented and undocumented status. We then estimate statistical models to analyze the determinants of departure and return according to legal status. Prior to 1986, Mexico-U.

Gender differences in adiponectin modulation of cardiac remodeling in mice deficient in endothelial nitric oxide synthase.

Left ventricular hypertrophy (LVH) is a risk factor for cardiovascular disease, a leading cause of death. Alterations in endothelial nitric oxide synthase (eNOS), an enzyme involved in regulating vascular tone, and in adiponectin, an adipocyte-derived secretory factor, are associated with cardiac remodeling. Deficiency of eNOS is associated with hypertension and LVH.

The Peruvian diaspora: portrait of a migratory process.

Since the 1980s and especially the 1990s, Peru has become a nation of emigrants. Emigration has become massive over the past two decades, and the Peruvian populations of the United States, Japan, and Spain have tripled in less than a decade. A survey of households in five localities, three urban and two rural, in and around Lima helps to reveal the special character of this emigration.

New World Orders: Continuities and Changes in Latin American Migration.

Although migration from Mexico to the United States is more than a century old, until recently most other countries in Latin America did not send out significant numbers of migrants to foreign destinations. Over the past thirty years, however, emigration has emerged as an important demographic force throughout the region. This article outlines trends in the volume and composition of the migrant outflows emanating from various countries in Latin America, highlighting their diversity with respect to country of destination; multiplicity of destinations; legal auspices of entry; gender and class composition; racial, ethnic, and national origins; and the mode of insertion into the receiving society.

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.

Calcineurin is a widely expressed and highly conserved Ser/Thr phosphatase. Calcineurin is inhibited by the immunosuppressant drug cyclosporine A (CsA) or tacrolimus (FK506). The critical role of CsA/FK506 as an immunosuppressant following transplantation surgery provides a strong incentive to understand the phosphatase calcineurin.

Lack of association between adiponectin levels and atherosclerosis in mice.

Objective: Adiponectin is an adipocyte-derived, secreted protein that is implicated in protection against a cluster of related metabolic disorders. Mice lacking adiponectin display impaired hepatic insulin sensitivity and respond only partially to peroxisome proliferator-activated receptor gamma agonists. Adiponectin has been associated with antiinflammatory and antiatherogenic properties; however, the direct involvement of adiponectin on the atherogenic process has not been studied.

Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero.

Studies were conducted to determine whether maternal substrate utilization during pregnancy affects fetal growth and predisposes offspring to metabolic disease. Female wild-type (WT) and glucose transporter 4 heterozygous mice (G4+/-, a model of altered peripheral substrate utilization) were fed high-fat diet (HFD, 35.5% fat) or control chow (C, 9.

Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice.

Trypanosoma cruzi infection results in an increase in myocardial NO and intense inflammation. NO modulates the T. cruzi-induced myocardial inflammatory reaction.

Design and evaluation of a passive alcove-based microfluidic mixer.

A novel passive microfluidic silicon mixer has been designed, optimized and fabricated. The architecture of the mixer consists of a simple "T" junction, made up by a 20 microm wide by 82 microm deep channel, followed by three repeats of an alcove, each with a triangular obstruction, arranged in a zigzag fashion. Numerical simulations were employed to optimize the geometry, particularly the dimensions of the alcoves, the relative orientation and the spacing between them, and the degree of intrusion associated with them.

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The history of Mexico-U.S. migration is characterized by a series of discrete phases during which levels and patterns of migration change primarily in response to shifts in U.

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.

Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability to appropriately expand subcutaneous adipose tissue may be an underlying reason for insulin resistance and beta cell failure.

Dyskinesis in Chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of mice.

We report on the use of centerline analysis of cardiac-gated magnetic resonance images to measure wall motion abnormalities in mice infected with Trypanosoma cruzi. To our knowledge, this is the first report of segmental wall motion abnormalities in an animal model of Chagas' disease. Chagas' disease patients with severe cardiac involvement exhibit mild hypokinesis in an extensive region of the left ventricle and dyskinesis in the apical region.

Role of transcription factor NFAT in glucose and insulin homeostasis.

Compromised immunoregulation contributes to obesity and complications in metabolic pathogenesis. Here, we demonstrate that the nuclear factor of activated T cell (NFAT) group of transcription factors contributes to glucose and insulin homeostasis. Expression of two members of the NFAT family (NFATc2 and NFATc4) is induced upon adipogenesis and in obese mice.