Publications by authors named "Jorge Duconge-Soler"
Non-Hispanic whites present with higher atrial fibrillation (AF) prevalence than other racial minorities living in the mainland USA. In two hospital-based studies, Puerto Rican Hispanics had a lower prevalence of atrial fibrillation of 2.5% than non-Hispanic Whites with 5.
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- The objective of the study was to compare the cost-effectiveness of pharmacogenetic-guided dosing of warfarin versus the standard dosing method using a Markov model.
- The analysis found that the pharmacogenetic strategy led to a slight increase in quality-adjusted life years (QALYs) but resulted in higher costs, resulting in an incremental cost-utility ratio (ICUR) indicating it was not cost-effective.
- The conclusion drawn suggests that pharmacogenetic-guided dosing for warfarin does not offer a superior cost-utility benefit compared to standard dosing practices.
Existing algorithms account for ~50% of observed variance in warfarin dose requirements after including common polymorphisms. However, they do not perform as well in populations other than Caucasians, in part because some ethno-specific genetic variants are overlooked. The objective of the present study was to identify genetic polymorphisms that can explain variability in warfarin dose requirements among Caribbean Hispanics of Puerto Rico.
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