Publications by authors named "Jorge Dourado"
Article Synopsis
- Bicyclic divinyl ketones can create different products when exposed to different light wavelengths.
- When they are hit with UV light, they make two main types of tricyclic unsaturated ketones which can change shape and react with other chemicals.
- Scientists used special calculations and experiments to confirm that these reactions follow a specific pattern called a vinylogous Type II Norrish pathway.
Heteroaromatic aldehydes have recently received a lot of attention as a scaffold for aminocatalytic functionalization as they allow for the construction of remote stereocenters and highly complex heterocyclic compounds. In this paper, we employ computational methods (M06-2X/cc-pVTZ//M06-2X/6-31 + G(d,p) and MP2/cc-pVTZ//M06-2X/6-31 + G(d,p)) to examine the abilities of secondary amines to activate several model heteroaromatic aldehydes by promoting loss of aromaticity and formation of the reactive trienamine intermediate. The hyperhomodesmotic equations used to assess the energy penalty for dearomatization show that the formation of the iminium ion decreases the energy cost for dearomatization, especially when X = O and S.
View Article and Find Full Text PDFN-Methyl-d-aspartate (NMDA) receptors are fundamental for the normal function of the central nervous system (CNS), and play an important role in memory and learning. Over-activation of these receptors leads to neuronal loss associated with major neurological disorders such as Parkinson's disease, Alzheimer's disease, schizophrenia, and epilepsy. In this study, 22 novel enantiopure bicyclic lactams were designed, synthesized, and evaluated as NMDA receptor antagonists.
View Article and Find Full Text PDFArticle Synopsis
- Malaria remains a significant global health issue, with rising drug resistance highlighting the need for new treatments.
- Researchers have developed a new class of antimalarial compounds based on the indolizinoindolone structure, synthesized effectively from (S)- or (R)-tryptophanol and 2-acyl benzoic acids.
- The novel compounds demonstrated strong efficacy against both the erythrocytic and liver stages of malaria parasites, especially one specific compound derived from (S)-tryptophanol, showing low toxicity and high stability.
Aziridination and unpredicted homologation reaction of N-sulfonylimines were achieved easily with a very simple, rapid and mild procedure through the use of diazomethane without the presence of any catalyst. The method represents an attractive alternative to metal-catalyzed processes.
View Article and Find Full Text PDF