Publications by authors named "Jorge Dores"
Article Synopsis
- - The study investigates how maternal lipid profiles, particularly triglycerides, in the third trimester relate to the risk of having larger-than-normal babies (LGA) in women with gestational diabetes mellitus (GDM).
- - Researchers analyzed data from 100 pregnant women with GDM, finding that higher pre-pregnancy BMI and elevated triglyceride levels were linked to an increased likelihood of delivering LGA newborns.
- - The results suggest that high triglyceride levels in late pregnancy are a significant predictor of LGA, regardless of factors like blood sugar control and weight gain during pregnancy, warranting further research on this relationship.
Background: The management of antidiabetic therapy in people with type 2 diabetes (T2D) has evolved beyond glycemic control. In this context, Brazil and Portugal defined a joint panel of four leading diabetes societies to update the guideline published in 2020.
Methods: The panelists searched MEDLINE (via PubMed) for the best evidence from clinical studies on treating T2D and its cardiorenal complications.
Background: Fragility fractures are increasingly recognized as a complication of type 2 diabetes mellitus (T2DM). The FRAX-Port® is a calculation tool that assesses the 10-year risk of either major and hip fracture, integrating several clinical risk factors, including T2DM. We aimed to evaluate the fracture risk in adults with T2DM and determine the rate of patients at high risk for fracture under anti-osteoporotic therapy.
View Article and Find Full Text PDFIntroduction: Simultaneous pancreas-kidney transplantation (SPKT) has demonstrated favorable impact on the progression of chronic complications in type-1 diabetes (T1D) and terminal chronic kidney disease (CKD). However, some CKD mineral and bone disorders (CKD-MBD) may persist, even after transplantation. There are only a few studies addressing the long-term progression of bone mineral density (BMD) in these patients.
View Article and Find Full Text PDFObjective: To evaluate the association between the dimension of deviation from appropriate gestational weight gain (GWG) and adverse maternofetal outcomes in women with gestational diabetes mellitus (GDM).
Methods: We performed a multicentric retrospective study based on the Portuguese GDM Database. Women were classified as within GWG, insufficient (IGWG) or excessive (EGWG) than the Institute of Medicine recommendations.
Liraglutide is a long-acting glucagon-like peptide-1 receptor agonist prescribed to diabetic patients for glycaemic control. To understand the impact of liraglutide in the real-world setting, this study analysed its effects in a Portuguese cohort of Type 2 diabetes patients. This was an observational, multicentric, and retrospective study that included 191 liraglutide-treated patients with at least 12 months of treatment.
View Article and Find Full Text PDFObjective: Metformin has emerged as a safe and effective pharmacological alternative to insulin in gestational diabetes mellitus (GDM), being associated with lower maternal weight gain and hypoglycemia risk. Nevertheless, glycemic control is unaccomplished in a considerable proportion of women only treated with metformin. We aim to determine the metformin monotherapy failure rate in GDM and to identify predictors of its occurrence.
View Article and Find Full Text PDFArticle Synopsis
- - Micromegaly is a type of acromegaly with high IGF-I levels but normal baseline growth hormone (bGH) levels, raising questions about whether it's a distinct condition or an early form of classic acromegaly.
- - In a study involving 74 acromegaly patients, 6 (8.1%) had normal bGH, showing older age at diagnosis, lower post-glucose GH and IGF-I levels, and a higher obesity prevalence compared to those with elevated bGH.
- - Most patients with normal bGH had microadenomas, and outcomes after treatment were similar to those with elevated bGH, suggesting that while micromegaly is less common, it displays unique characteristics
Article Synopsis
- Gestational trophoblastic disease (GTD) is a rare disorder that can lead to complications like secondary clinical hyperthyroidism, particularly in perimenopausal women.
- A case presented involved a 50-year-old woman who showed symptoms like severe abdominal pain, abnormal bleeding, and hormonal imbalances, ultimately diagnosed with GTD and a hydatidiform mole after surgery.
- The management included anti-thyroid medication and surgery, after which her thyroid function normalized, emphasizing the need to consider GTD when diagnosing thyrotoxicosis in this demographic.
Aim: To compare fetomaternal outcomes between GDM pregnant women with twin versus singleton pregnancies and then between women with GDM versus non-GDM twin pregnancies.
Methods: We performed a retrospective study including GDM pregnant women with both twin and singleton pregnancies followed in our tertiary center between 2011 and 2018. The fetomaternal characteristics of each group were compared.
Objective: To compare the risk of severe adverse pregnancy complications in women with preexisting diabetes.
Research Design And Methods: Multinational, prospective cohort study to assess the prevalence of newborns free from major congenital malformations or perinatal or neonatal death (primary end point) following treatment with insulin detemir (detemir) versus other basal insulins.
Results: Of 1,457 women included, 727 received detemir and 730 received other basal insulins.
Aims: To examine clinical parameters, glycemic control, folic acid supplementation, and the presence of other chronic diseases during early pregnancy in the EVOLVE study population (women with pre-existing diabetes treated with injectable glucose-lowering drugs).
Methods: Cross-sectional baseline evaluation of EVOLVE: an international, multicenter, non-interventional study investigating the safety of injectable glucose-lowering drugs in pregnant women with pre-existing type 1 (T1D) or type 2 diabetes (T2D). Data were collected at enrollment visit interviews before gestational week 16.
Objective: To evaluate the association between HbA1c levels measured in the third trimester and the risk for large for gestational age (LGA) in neonates of mothers affected by gestational diabetes mellitus (GDM). Secondarily, we aimed to identify an ideal cut-off for increased risk of LGA amongst pregnant women with GDM.
Methods: Observational retrospective review of singleton pregnant women with GDM evaluated in a diabetes and pregnancy clinic of a tertiary and academic hospital.
Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study.
Clin Diabetes Endocrinol
January 2021
Background: We intended to estimate the proportion hypoglycemic/hyperglycemic emergency episodes in treated diabetes mellitus (DM) patients admitted to a hospital ward, and calculate the prevalence of risk factors for hypoglycemia and diabetic complications.
Methods: In this cross-sectional, multicentered study, the observational data was collected by physicians from patient's hospitalization to discharge/death. Statistical tests were 2-tailed considering 5% significance level.
Objective: To analyse changes in the characteristics of hypoglycaemic episodes treated in the emergency room of a tertiary hospital in Portugal between 2012 and 2016.
Research Design And Methods: We retrospectively analysed all emergency room reports for patients discharged with a diagnosis of hypoglycaemia between 2012 and 2016 and analysed demographic characteristics, type of diabetes and treatments, causes of hypoglycaemia and discharge destination. Patients without diabetes were excluded.
Introduction: Hypoglycemia leading to hospitalization is associated with adverse economic outcomes, although the real burden is unknown. The HIPOS-WARD (Hypoglycemia In Portugal Observational Study-Ward) aimed to characterize ward admissions due to hypoglycemia episodes in treated patients with diabetes and assess their economic impact to the National Health System.
Methods: Observational, cross-sectional study, conducted in 16 Portuguese centers for 22 months.
Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida.
View Article and Find Full Text PDFArticle Synopsis
- * Analyzing data from 4,490 women across Portuguese health institutions, it was found that lower education levels (≤ 9th grade) were associated with a significantly higher risk of developing these disorders post-partum compared to those with university degrees.
- * The findings suggest that targeted interventions for women with lower educational attainment could help reduce the prevalence of post-partum glucose metabolism disorders in this population.
Metformin in gestational diabetes mellitus: predictors of poor response.
Eur J Endocrinol
January 2018
Objective: Metformin can be regarded as a first-line treatment in gestational diabetes mellitus (GDM) due to its safety and effectiveness. However, a proportion of women do not achieve adequate glycemic control with metformin alone. We aim to identify predictors of this poor response to metformin.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the prevalence of severe hypoglycaemia in type 2 diabetes (T2DM) patients needing emergency room assistance, particularly focusing on different antihyperglycaemic agents (AHAs).
- In a nationwide cross-sectional study, 425,706 ER admissions were recorded, revealing a hypoglycaemia prevalence of 0.074%, with over half of the patients on insulin therapy and many experiencing hypoglycaemic episodes due to missed meals.
- The results showed that those on secretagogue therapies were more frequently hospitalized than those on insulin, highlighting the need for individualized diabetes treatment to reduce the risk of severe hypoglycaemia.
The cost of managing severe hypoglycemic episodes in Type 2 diabetic patients.
Expert Rev Pharmacoecon Outcomes Res
December 2016
Article Synopsis
- Severe hypoglycemia is a serious complication of diabetes that leads to increased healthcare costs and impacts on patient health, which the study aims to measure from a societal perspective.
- Conducted in Portugal, the study analyzed data from 238 Type-2 diabetes patients to assess healthcare resource use and costs associated with severe hypoglycemic events, including expenses from emergency services and hospital stays.
- The findings revealed that each hypoglycemic episode costs an average of €1493, with hospitalization costs being significant, highlighting the financial burden these events place on the healthcare system, particularly the National Health Service.
Impact of gestational weight gain on obstetric and neonatal outcomes in obese diabetic women.
BMC Pregnancy Childbirth
October 2015
Background: Both obesity and gestational diabetes mellitus are increasing in prevalence, being a major health problem in pregnancy with independent and additive impact on obstetrics outcomes. It is recognized that inadequate gestational weight gain is an independent risk factor for pregnancy-related morbidity. The aim of this study was to evaluate the effect of gestational weight gain on obstetric and neonatal outcomes in obese women with gestational diabetes.
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