New Bacteriophages Members of the Family Specific for ST258.

Background: Carbapenem-resistant , particularly isolates classified as sequence-type 258 (ST258), are multidrug-resistant strains that are strongly associated with poor-prognosis nosocomial infections, as current therapeutic options are limited and ineffective. In recent years, phage therapy has emerged as a promising treatment option for these scenarios.

Methodology And Results: We report the isolation and characterization of three new phages against ST258 strains recovered from Machángara river wastewater.

Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales.

Introduction: Carbapenem resistance in members of order Enterobacterales is a growing public health problem causing high mortality in developing and industrialized countries. Its emergence and rapid propagation worldwide was due to both intercontinental spread of pandemic strains and horizontal dissemination via mobile genetic elements (MGE) such as plasmids and transposons.

Objective: To describe MGE carrying carbapenem resistance genes in Enterobacterales which have been reported in South America.