Publications by authors named "Jorge Alberto Roacho-Perez"
Objectives: Lipid nanoparticles, as a nucleic acid delivery system, have been used as an alternative to treat ocular diseases, since they can cross the ocular barrier and efficiently transfecting nucleic acids to various cells of the eye. The size influences the transfection of genes, biological distribution, diffusion, and cellular uptake. It is therefore important to establish a relationship between size, formulation, and encapsulation percentage.
View Article and Find Full Text PDFA Review on the Efficacy and Safety of Nab-Paclitaxel with Gemcitabine in Combination with Other Therapeutic Agents as New Treatment Strategies in Pancreatic Cancer.
Life (Basel)
February 2022
Article Synopsis
- - Pancreatic cancer has a high mortality rate, and the standard first-line treatment is a combination of nab-paclitaxel and gemcitabine, but more effective therapies are needed to improve patient outcomes.
- - A review analyzed seven studies investigating the combination of nab-paclitaxel and gemcitabine with other agents like ibrutinib and cisplatin to determine their efficacy and safety for treating pancreatic cancer.
- - The review suggests that while these combinations show promise, further research is necessary to assess the safety and effectiveness of these triple regimens for patients with untreated metastatic pancreatic cancer.
Background And Aims: Acute lymphoblastic leukemia (ALL) is the most common cancer in the pediatric population; ∼80% of the cases show some translocation. Translocations that result in ALL are due to chromosome breaks. However, the exact mechanisms that cause these breaks have not been well studied.
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