Therapeutic opportunities in targeting the protective arm of the renin-angiotensin system to improve insulin sensitivity: a mechanistic review.

In recent years, the knowledge of the physiological and pathophysiological roles of the renin-angiotensin system (RAS) in glucose metabolism has advanced significantly. It is now well-established that blockade of the angiotensin AT receptor (ATR) improves insulin sensitivity. Activation of the AT receptor (ATR) and the MAS receptor are significant contributors to this beneficial effect.

Acute In Vivo Administration of Compound 21 Stimulates Akt and ERK1/2 Phosphorylation in Mouse Heart and Adipose Tissue.

The angiotensin II type 2 (AT) receptor has a role in promoting insulin sensitivity. However, the mechanisms underlying the AT receptor-induced facilitation of insulin are still not completely understood. Therefore, we investigated whether acute in vivo administration of AT receptor agonist compound 21 (C21) could activate insulin signaling molecules in insulin-target tissues.