Publications by authors named "Jorge A Florindez"
Article Synopsis
- Follicular lymphoma (FL) and marginal zone lymphoma (MZL) generally allow for long survival, but high-grade transformation (HGT) into diffuse large B-cell lymphoma significantly lowers this survival rate.
- A study using a large database from 2000 to 2020 revealed that the incidence of HGT is low in FL and MZL, peaking within the first two years after diagnosis.
- The research found that upfront treatment increases the risk of HGT in FL but not in MZL, and while treatment barely impacts overall survival in FL, it has no effect on survival outcomes in MZL.
Article Synopsis
- Breast extranodal marginal zone lymphoma (EMZL) is a rare type of cancer, with this study being the largest retrospective analysis of 13 patients focusing on its characteristics and treatment results.
- Most patients were in early stages (I-II), but about 30% had advanced stage IV disease due to hidden issues like bone marrow involvement; additionally, two-thirds of cases were not detected on PET/CT scans.
- The results showed promising outcomes with a 68.7% rate of progression-free survival and 80.2% overall survival over a median follow-up of 3.1 years, indicating that radiation therapy can effectively manage localized breast EMZL.
Cancers (Basel)
April 2021
Article Synopsis
- * The most common treatment was observation (31%), followed by radiation therapy (23%), with a median overall survival of 17.3 years, although some patients had shorter survival rates compared to the general population; those receiving radiation therapy had similar survival outcomes.
- * Factors linked to shorter lymphoma-specific survival included being over 60 years old, higher grade transformation, and primary lung involvement, while primary skin location was associated with better survival outcomes, indicating radiation therapy as the preferred treatment for localized EMZL. *
Am J Hematol
November 2020
Article Synopsis
- A study analyzed the survival rates of 248 chemotherapy-treated patients with plasmablastic lymphoma (PBL) diagnosed between 2010 to 2016, mainly focusing on demographic data and clinical outcomes.
- The majority of patients were young males, with the most common primary locations of the cancer being in the oral cavity and gastrointestinal tract.
- Results indicated that patients with oral primary locations had better overall and lymphoma-specific survival rates, while HIV status did not significantly impact survival outcomes.
Article Synopsis
- Splenic marginal zone lymphoma (SMZL) is a rare cancer with variable treatment methods, and a large study investigated how different treatments affected patient survival.
- The study analyzed 1,671 patients diagnosed with SMZL between 1999 and 2016, looking at factors like age, ethnicity, transformation to a more aggressive form of lymphoma (DLBCL), and symptoms.
- Results showed that treatment type (observation, splenectomy, chemotherapy, or a combination) did not significantly affect survival rates, while older age and having B-symptoms were associated with poorer overall survival.
Clin Nephrol
February 2015
Article Synopsis
- Anti-glomerular basement membrane (GBM) disease is a serious kidney disorder caused by autoantibodies against type IV collagen, with some patients also showing associated antineutrophil cytoplasmic antibodies (ANCA).
- Factors leading to this immune response are still unclear, but genetics and environmental influences are believed to contribute, with molecular mimicry possibly playing a role.
- A case study highlights a 66-year-old woman with dengue who developed anti-GBM disease and ANCA, emphasizing the need for awareness of autoimmune kidney complications in dengue patients.
