Publications by authors named "Jorfelia J Chilaule"
Article Synopsis
- - Mozambique added the Rotarix vaccine to its National Immunization Program in September 2015, which led to the first detection of new rotavirus A genotypes (G9P[4] and G9P[6]) in the country.
- - Research involved sequencing the whole genomes of 47 rotavirus strains found from 2015 to 2018, revealing diverse genomic constellations among the detected G9 strains.
- - Findings underscore the importance of ongoing genomic monitoring of rotavirus strains in Mozambique, emphasizing a One Health approach to address zoonotic infections that can impact child health.
Comorbidities are defined as the simultaneous occurrence of two or more diseases within the same individual. Comorbidities can delay a patient's recovery and increase the costs of treatment. Assessing comorbidities can provide local health care policy-makers with evidence of the most common multi-health impairments in children.
View Article and Find Full Text PDFEnteroviruses (EV) are predominantly enteric viruses, present in all parts of the world causing disease in humans with a broad spectrum of clinical presentations. The purpose of this study was to identify non-polio enteroviruses (NPEV) in stool samples collected from children with acute gastroenteritis (AGE) symptoms of unknown etiology in four provinces (Maputo, Nampula, Sofala and Zambézia) of Mozambique. From June 2014 to March 2018, 327 stool samples were collected from children hospitalized with AGE in health care units.
View Article and Find Full Text PDFNorovirus (NoV) is the second most important cause of viral diarrheal disease in children worldwide after rotavirus and is estimated to be responsible for 17% of acute diarrhea in low-income countries. This study aimed to identify and report NoV genotypes in Mozambican children under the age of five years with acute diarrhea. Between May 2014 and December 2015, stool specimens were collected within the Mozambique Diarrhea National Surveillance (ViNaDia) and tested for NoV genogroups I (GI) and II (GII) using conventional reverse transcriptase-polymerase chain reaction (RT-PCR).
View Article and Find Full Text PDFRotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019).
PLoS One
November 2021
Article Synopsis
- Mozambique launched the Rotarix® rotavirus vaccine in September 2015, but Nampula province still sees high rates of Rotavirus A infections and various genotypes.
- A study conducted in Nampula's Central Hospital collected data from children under five to assess the frequency of RVA infection and associated factors before and after the vaccine was introduced.
- Results showed a drop in RVA infections from 34.9% pre-vaccine to 21.8% post-vaccine, with partially vaccinated children having the highest infection rates, indicating a need for further research on vaccination effectiveness and optimization strategies.
Intestinal protozoa in hospitalized under-five children with diarrhoea in Nampula - a cross-sectional analysis in a low-income setting in northern Mozambique.
BMC Infect Dis
February 2021
Background: In Mozambique, infection by intestinal parasites is reported all over the country. However, infection in children with diarrhoea is mostly focused in the southern region of Mozambique. This work aims to determine the frequency and potential risk factors for infection by Cryptosporidium spp.
View Article and Find Full Text PDFRotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea - a cross-sectional study in four provinces of Mozambique.
BMC Infect Dis
January 2021
Background: Mozambique has a high burden of group A rotavirus (RVA) infection and chronic undernutrition. This study aimed to determine the frequency and potential risk factors for RVA infection in undernourished children under 5 years old with diarrhoea in Mozambique.
Methods: The analysis was conducted using data from March 2015 to December 2017, regarding children under 5 years old with at least one type of undernutrition.
Mozambique introduced the Rotarix vaccine (GSK Biologicals, Rixensart, Belgium) into the National Immunization Program in September 2015. Although G1P[8] was one of the most prevalent genotypes between 2012 and 2017 in Mozambique, no complete genomes had been sequenced to date. Here we report whole genome sequence analysis for 36 G1P[8] strains using an Illumina MiSeq platform.
View Article and Find Full Text PDFBackground: Intestinal parasites such as Cryptosporidium spp., Giardia lamblia and Entamoeba histolytica can cause severe diarrhea, especially among children in developing countries. This study aims to determine the frequency of Cryptosporidium spp.
View Article and Find Full Text PDFBackground: Mozambique introduced rotavirus vaccine (Rotarix, GSK Biologicals) in the National Immunization Program in September 2015 with the objective of reducing the burden of total diarrheal disease and specifically severe rotavirus disease. This study aimed to evaluate the early impact of rotavirus vaccine in reducing all-cause diarrhea and rotavirus-specific hospitalizations.
Methods: We analysed stool specimens collected from children under five years old, between January 2014 and June 2017 within the National Surveillance for Acute Diarrhea.