Comprehensive Characterization of the LSD1 Small Molecule Inhibitor Class in Oncology.

Lysine-specific demethylase 1 (LSD1 or KDM1A) is a chromatin modifying enzyme playing a key role in the cell cycle and cell differentiation and proliferation through the demethylation of histones and nonhistone substrates. In addition to its enzymatic activity, LSD1 plays a fundamental scaffolding role as part of transcription silencing complexes such as rest co-repressor (CoREST) and nucleosome remodeling and deacetylase (NuRD). A host of classical amine oxidase inhibitors such as tranylcypromine, pargyline, and phenelzine together with LSD1 tool compounds such as SP-2509 and GSK-LSD1 have been extensively utilized in LSD1 mechanistic cancer studies.

[Spanish home enteral nutrition registry of the year 2014 and 2015 from the NADYA-SENPE Group].

Objective: To present the results of the Spanish home enteral nutrition (HEN) registry of the NADYA-SENPE group for the years 2014 and 2015. Methods: From January 1st 2014 to December 31st 2015 the HEN registry was recorded and afterwards a further descriptive and analytical analysis was done. Results: In 2014, 3749 patients were recorded, and 4202 in 2015; prevalence was 80.

Advances in the development of histone lysine demethylase inhibitors.

The covalent modification of histones is closely associated with regulation of gene transcription. Chromatin modifications have been suggested to represent an epigenetic code that is dynamically 'written' and 'erased' by specialized proteins, and 'read', or interpreted, by proteins that translate the code into gene expression changes. Initially thought to be an irreversible process, histone methylation is now known to be reversed by demethylases, FAD dependent amineoxidases and by iron(II)-alpha-ketoglutarate dependent deoxygenases of the Jumonji family.

Estimate of specific energy expenditure of fat-free mass and fat mass in children receiving total parenteral nutrition.

Objectives: Simple methods for calculation of the energy expenditure may be useful for clinicians involved in the treatment of nutritional disorders in children. The aims of this study were to (1) estimate the specific energy expenditure (SEE) of fat mass (FM) and fat-free mass (FFM) and (2) determine a sensitive predictive indicator of resting energy expenditure (REE).

Methods: The REE of 26 children receiving longterm TPN, was measured by long-term indirect calorimetry.

Minimum data set for nutritional intervention studies in elderly people.

Malnutrition, considered for the purpose of the present data set as undernutrition, is a major risk factor of mortality in elderly people. Such protein-energy malnutrition should be detected as soon as possible. Once established, this malnutrition state must be corrected by appropriate diet, supplementation, artificial nutrition, or therapeutic treatment.

Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation.

Background: The diversity of the Mediterranean diet and the heterogeneity of acquired genetic alterations in colorectal cancer (CRC) led us to examine the possible association between dietary factors and mutations, such as Ki-ras mutations, in genes implicated in the pathogenesis of these neoplasms.

Patients And Methods: The study was based on 246 cases and 296 controls. For the molecular study only 117 patients with Ki-ras tumor expression were included.