Resection extent and BRAF V600E mutation status determine postoperative tumor growth velocity in pediatric low-grade glioma: results from a single-center cohort analysis.

Purpose: Despite excellent long-term overall survival rates, pediatric low-grade gliomas (pLGG) show high variety of clinical behavior regarding progress or senescence post incomplete resection (IR). This study retrospectively analyzes tumor growth velocity (TGV) of pLGG before surgery and after IR to investigate the impact of surgical extent, tumor location and molecular BRAF status on postoperative residual tumor growth behavior.

Methods: Of a total of 172 patients with pLGG receiving surgical treatment, 107 underwent IR (66%).

Lack of correlation of overnight monitoring data and lumbar infusion data in iNPH patients.

Objective: Hydrodynamic theories of idiopathic normal pressure hydrocephalus (iNPH) favor a decrease in compliance as an important underlying principle of the disease's immanent pathophysiology. ICP overnight monitoring (ONM) and lumbar infusion study (LIS) are both established methods that aid as supplemental tests in the selection of shunt-responsive patients. Pulse wave amplitude (AMP) and RAP index are measures derived from ONM and are related to intracranial compliance.