Publications by authors named "Jordana C Oliveira"

To compare the effects of 8 weeks of two types of interval training, Sprint Interval Training (SIT) and High-Intensity Interval Training (HIIT), on anthropometric measures and cardiorespiratory fitness in healthy young women. A randomized clinical trial in which 49 young active women [age, 30.4 ± 6.

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Background: Leishmania braziliensis is the most prevalent species isolated from patients displaying cutaneous and muco-cutaneous leishmaniasis in South America. However, there are difficulties for studying L. braziliensis pathogenesis or response to chemotherapy in vivo due to the natural resistance of most mouse strains to infection with these parasites.

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Article Synopsis
  • Miltefosine is currently the only oral drug for leishmaniasis treatment, approved for visceral leishmaniasis in India but undergoing trials for cutaneous leishmaniasis in the Americas. This study focuses on its effectiveness against visceral leishmaniasis caused by Leishmania infantum chagasi, using hamsters as an experimental model.
  • Researchers created a transgenic line of Leishmania infantum chagasi that expresses luciferase, allowing for quantification of parasite load through bioluminescence; the growth and drug susceptibility of this line were similar to wild-type parasites.
  • The study found that miltefosine effectively reduced parasite burden and extended the survival of hamsters
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