Habituation of the EEG arousal response in rats: short- and long-term effects, frequency specificity, and wake--sleep transfer.

Presentation of auditory stimuli over interstimulus intervals (ISIs) of several minutes to sleeping rats produced significant habituation of the electroencephalographic (EEG) arousal response. The arousal response habituated to an asymptote after only two or three stimulus presentations. Little or no spontaneous recovery occurred between sessions separated by 24 or 72 hr.

Physical examinations in inner-city preschools.

This paper describes the physical examination program started in March 1974 and carried out by the Anacostia Headstart Program in Washington DC. Annual totals of 362, 274, and 458 preschool children were examined in 16 schools during the 1973-1974, 1974-1975, and 1975-1976 school years, respectively. For these years, 8, 9, and 12 percent, respectively, had heart murmurs.

Factors Involved in in Vitro Stabilization of Nitrate Reductase from Cotton (Gossypium hirsutum L.) Cotyledons.

Experiments were conducted to determine if pretreatment of cotton (Gossypium hirsutum L.) plants resulted in differential in vitro stabilities of nitrate reductase (NR) activity. Although NR activity declines markedly during the second half of the daily light period, in vitro NR stability is not modified by time of harvest.

Kinetics of early time calcium oxalate nephrolithiasis.

This paper examines the kinetics of calcium deposition in rat kidneys after an intraperitoneal sodium oxalate injection. From the results we conclude that only a limited portion of tubular surface is available for adsorption of calcium oxalate crystals, that adsorpption of calcium oxalate crystals onto tubular epithelium is a process of greater than first order with regard to the dose, and that the washout of retained particles from the tubules is a first-order process as related to time. Also, we conclude that in these animals, which were subjected to a large oxalate challenge, the deposition of calcium oxalate crystals is virtually all intratubular.

Changes in oxygen consumption induced by fentanyl and thiopentone during balanced anaesthesia.

Changes in whole body oxygen consumption due to bolus infusions of fentanyl and thiopentone given during "balanced anaesthesia" have been examined in 17 patients. It has been shown that fentanyl causes an average decrease in oxygen consumption of 4.9, 8.

Correlation of oxygen uptake and cardiovascular dynamics during N2O-fentanyl and N2O-thiopental anesthesia in the dog.

The relationship between changes in wholebody O2 consumption (VO2) and cardiovascular dynamics during changing levels of N2O-fentanyl and N2O-thiopental anesthesia was determined in 24 dogs. Dose-dependent reductions in VO2, mean blood pressure, and cardiac output occurred with infusion of fentanyl and thiopental. Painful stimuli increased VO2 during light anesthesia but not during deeper levels of anesthesia.

Reconsideration of orchiectomy in the treatment of advanced prostatic carcinoma.

The results of a large randomized prospective clinical trial conducted by the Veterans Administration Co-operative Urological Research Group (VACURG) in 1968 are updated and reevaluated. In this study, placebo, diethylstilbestrol (DES, 5 mg/day), orchiectomy plus placebo, and orchiectomy plus DES were compared in patients whose conditions were initially diagnosed as stage III and IV carcinoma of the prostate. Results showed that orchiectomy alone or in combination with estrogen did not improve overall survival rates in stage III and IV carcinoma of the prostate.

Lassa fever: response to an imported case.

In February, 1976, a Peace Corps worker returned to the United States from Sierra Leone with an undiagnosed illness later recognized as Lassa fever. To assess the risk of transmission and to contain a potential outbreak, we identified 552 contacts as having had exposure to the patient before the start of strict isolation procedures, and maintained intensive surveillance on these contacts for 21 days. At the end of the surveillance period, no illness had developed in contacts.

Movement and Endogenous Levels of Abscisic Acid during Water-Stress-induced Abscission in Cotton Seedlings.

In an effort to investigate possible involvement of abscisic acid (ABA) in foliar abscission processes, its movement and endogenous levels were examined in cotyledons taken from cotton seedlings (Gossypium hirsutum L.) subjected to varying degrees of water deficit, a condition which initiates leaf abscission. Using a pulse-labeling technique to avoid complications of uptake and exit from the tissue, ABA-1-(14)C movement was observed in both basipetal and acropetal directions in cotyledonary petioles taken from well watered, stressed, and rewatered plants.

Postsorters' rubber fingerstall dermatitis.

An outbreak of rubber fingerstall dermatitis in a Danish post office was found to be caused by minute amounts of isopropylphenyl-para-phenylenediamine (IPPD) in the fingerstalls. The presence of IPPD in the fingerstalls could not be explained by the manufacturer and had to be confirmed by gas chromatographic analysis.

Abscission responses to moisture stress, auxin transport inhibitors, and ethephon.

The three abscission-inducing agents - water stress, Ethephon, and auxin transport inhibitors-acted synergistically to promote leaf fall in cotton (Gossypium hirsutum L.). However, the synergism was primarily between stress and Ethephon.

Auxin Transport as Related to Leaf Abscission during Water Stress in Cotton.

Plant water deficits reduced the basipetal transport of auxin in cotyledonary petiole sections taken from cotton (Gossypium hirsutum L.) seedings. A pulse-labeling technique was employed to eliminate complications of uptake or exit of (14)C-indoleacetic acid from the tissue.

Delayed hypersensitivity in females. The development of allergic contact dermatitis in females during the comparison of two predictive patch tests.

Ten chemically different compounds were applied to the skin of the backs of male and female volunteers to induce delayed hypersensitivity responses. The 10 compounds had a low, moderate, high or unknown allergenic potential and were divided among five test panels (modified Draize) consisting of 150 subjects each. In each panel, 75 subjects (mean age 31 years) were always male prisoners (50% Caucasians) and the remaining 75 subjects (greater than 90% Caucasians) were divided, age-matched free males and females (mean age 24 years).