Publications by authors named "Jordan T Pepper"
Article Synopsis
- RAD51C is a gene linked to an increased risk of breast, ovarian, and prostate cancers, but its structural and functional roles are not fully understood, limiting mutation interpretations to its function in homology-directed repair (HDR).
- The study provides a co-crystal structure of RAD51C with XRCC3 and ATP analog, revealing important details about RAD51C’s roles in DNA replication stability and its potential interaction interfaces related to cancer mutations.
- The findings suggest that RAD51C contributes to DNA replication stress response and could help in understanding how certain mutations may lead to tumor development, aiding in the categorization and functional testing of cancer-related mutations.
Adsorption of cell-penetrating peptide Tat and polycation luviquat FC-370 to triticale microspore exine.
Colloids Surf B Biointerfaces
September 2017
Microspores are the pre-gametophyte stage of pollen, and have proven to be a successful tissue culture material for the production of doubled haploid plants. Microspore culture has also been used as a platform for the production of transgenic plants. The use of cell-penetrating peptides (CPPs) as transfection agents in microspores has been previously demonstrated, but at low efficiencies.
View Article and Find Full Text PDFCell-penetrating peptides (CPPs) are short 8-30 amino-acid oligopeptides that act as effective transducers of macromolecular cargo, particularly nucleic acids. They have been implemented in delivering dsDNA, ssDNA, and dsRNA into animal and plant cells. CPPs and nucleic acids form nano-complexes that are often 100-300 nm in size but still effectively transit the cell membrane of animal cells, but are less effective with plant cells due to the plant cell wall.
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