Publications by authors named "Jordan T Holler"

Article Synopsis
  • Previous attempts at creating safer antifungal treatments were based on an outdated model, focusing on how they damage fungal cell membranes.
  • Researchers discovered that the key to the antifungal action of amphotericin B, a potent but kidney-damaging drug, lies in its ability to form sponge-like aggregates that extract crucial components from fungi.
  • By modifying amphotericin B to selectively extract ergosterol without harming human kidneys, scientists developed a new polyene compound, AM-2-19, which shows promise as a safer and effective treatment against various fungal infections.
View Article and Find Full Text PDF

Purpose: To determine the incidence of and risk factors for symptomatic venous thromboembolism (VTE) after hip arthroscopy (HA) and thromboprophylaxis prescription utilization for this procedure.

Methods: The PearlDiver Mariner database was queried using Current Procedural Terminology codes to identify adult patients (aged ≥ 18 years) who underwent HA between 2010 and 2020. Patient demographic information, including age, oral contraceptive use, and medical comorbidities, as well as perioperative thromboprophylaxis utilization, was recorded using International Classification of Diseases codes and National Drug Codes.

View Article and Find Full Text PDF

Purpose: To determine the rate of symptomatic venous thromboembolism (VTE) among patients undergoing arthroscopic knee procedures, risk factors associated with postoperative VTE, and current perioperative thromboprophylaxis prescription patterns associated with this population in the United States.

Methods: Medical records for patients ≥18 years of age were queried from the Mariner database using Current Procedural Terminology codes for knee arthroscopy performed in the United States from 2010 to 2020 in this cross-sectional study. Patients who received thromboprophylaxis and those diagnosed with VTE, including deep-vein thrombosis or pulmonary embolism, within 90 days of surgery were identified using International Classification of Diseases and National Drug Codes.

View Article and Find Full Text PDF

Purpose: We describe the lived experience of adults with acquired buried penis (AABP) through thematic analysis of patient interviews. We examine the challenges that patients face and the impacts of surgery.

Materials And Methods: This mixed-methods study utilized validated instruments and semi-structured interviews to capture pre- and postsurgical outcomes.

View Article and Find Full Text PDF

Peyronie's disease (PD) is a fibrotic disorder of the tunica albuginea that may result in penile deformity, pain, a palpable plaque, and erectile dysfunction. In order to understand the psycho-sexual impacts of PD on patients and their partners, we selected three online forums containing the largest number of threads on PD. Threads focusing on the psycho-sexual impacts posted from January 1, 2011 to January 1, 2021 were compiled, and thematic analysis was performed on Dedoose.

View Article and Find Full Text PDF

Background: Open fractures, especially of the tibia, require prompt intervention to achieve optimal patient outcomes. While open tibial shaft fractures are common injuries in low- and middle-income countries (LMICs), there is a dearth of literature examining delays to surgery for these injuries in low-resource settings. This study investigated risk factors for delayed management of open tibial fractures in Tanzania.

View Article and Find Full Text PDF

Introduction: We examined the characteristics and financial outcomes of online crowdfunding campaigns for patients with major urological cancers in the U.S.

Methods: This cross-sectional study analyzed publicly available data from GoFundMe, the largest online medical crowdfunding service, via automated web scraping.

View Article and Find Full Text PDF
Article Synopsis
  • Amphotericin B (AmB) is a toxic antifungal that works by forming aggregates that extract ergosterol from yeast cell membranes, which kills the yeast.
  • Recent research has identified the structural characteristics of these antifungal aggregates using advanced NMR techniques and modeling, revealing that AmB primarily forms asymmetric homodimers.
  • The arrangement of these homodimers creates a lattice structure with voids similar in size to sterols, hinting at a potential mechanism for AmB's effectiveness and its ability to capture sterols in a biologically active manner.
View Article and Find Full Text PDF

Objective: To identify the current formats of standardized letters of recommendation (SLORs) and evaluate their characteristics, the distribution of applicants' ratings, correlation between SLOR domain ratings and conventional application metrics, and potential biases.

Methods: We evaluated all applications submitted to our residency program for the 2020-2021 urology match. Two main formats of SLOR were identified.

View Article and Find Full Text PDF

Objective: To assess provider and practice characteristics that drive opioid prescription behavior using the American Urological Association census data.

Methods: Stratified weighted analysis using 1,157 census samples was performed to represent 12,660 urologists who practiced in the United States in 2018. We compared urologists according to their opioid prescription patterns to evaluate factors and motivations behind opioid use in the post-operative setting.

View Article and Find Full Text PDF

Case: A 29-year-old man previously treated with closed reduction and intramedullary nail (IMN) fixation for a right tibial shaft fracture presented with complaint of the foot pointing outward compared with uninjured side. He was diagnosed with tibial malrotation, and a novel intraoperative imaging technique was used for correction.

Conclusion: Literature suggests that the prevalence of tibial malrotation after IMN fixation is greater than previously thought.

View Article and Find Full Text PDF

Objective: To describe factors associated with Quality improvement and patient safety (QIPS) participation using 2018 American Urological Association Census data. QIPS have become increasingly important in medicine. However, studies about QIPS in urology suggest low levels of participation, with little known about factors predicting non-participation.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzed playground equipment-related injuries in children aged 17 and under using data from the National Electronic Injury Surveillance System from 1995 to 2019, totaling over 184,000 cases.
  • An estimated 5.3 million emergency department visits for playground injuries occurred, with most injuries affecting school-aged (42.7%) and preschool children (35.3%), and climbing apparatuses being the most common source of injuries.
  • While overall injuries have decreased since 2012, there has been a troubling rise in reported concussions, indicating the need for increased focus on preventing serious head injuries in playground settings.
View Article and Find Full Text PDF

Unlabelled: Managing lower extremity fractures complicated by large soft-tissue defects is challenging for surgeons in low- and middle-income countries, and long-term quality of life (QOL) for these patients is unclear.

Methods: We examined QOL, surgical complications, and longitudinal outcomes in 10 patients with Gustilo-Anderson Classification Type IIIB open tibia fractures seen at an orthopedic institute in Tanzania, from December 2015 to March 2017. Patients completed follow-up at 2-, 6-, 12-, 26-, and 52-week time points, and returned for qualitative interviews at 2.

View Article and Find Full Text PDF

Background: An increasing number of traumatic injuries in low- and low-middle-income countries (LICs/LMICs) have coexisting injuries requiring soft-tissue coverage (flaps). Yet, there is a lack of subspecialty care and flap training in Latin America. This study assesses the effectiveness of a surgical skills training course in improving rotational and free flap knowledge and identifies barriers to performing these types of flaps.

View Article and Find Full Text PDF

Background: Appropriate management of soft tissue injury associated with orthopedic trauma is challenging in low- and middle-income countries (LMICs) due to the lack of available reconstructive surgeons. The Surgical Management and Reconstructive Training (SMART) course teaches orthopedic surgeons reconstructive techniques aimed at improving soft tissue management. This study aims to identify additional barriers to implementing these techniques for surgeons in LMICs who have attended SMART courses.

View Article and Find Full Text PDF

Objective: Our goal was to compare the perceptions of overseas orthopaedic volunteers and their hosts in low- and middle-income countries (LMICs) regarding the role of international volunteerism. We also sought to determine if differences in perception exist between trainee and fully trained orthoapedic surgeon volunteers.

Methods: Surveys with similar multiple-choice and open-ended questions were administered to 163 Health Volunteers Overseas orthopaedic volunteers (response rate 45%) and 53 members of the host orthopaedic staff (response rate 40%).

View Article and Find Full Text PDF