Bedmap3 updated ice bed, surface and thickness gridded datasets for Antarctica.

We present Bedmap3, the latest suite of gridded products describing surface elevation, ice-thickness and the seafloor and subglacial bed elevation of the Antarctic south of 60 °S. Bedmap3 incorporates and adds to all post-1950s datasets previously used for Bedmap2, including 84 new aero-geophysical surveys by 15 data providers, an additional 52 million data points and 1.9 million line-kilometres of measurement.

Evaluating the timecourses of morpho-orthographic, lexical, and grammatical processing following rapid parallel visual presentation: An EEG investigation in English.

Theories of language processing - and typical experimental methodologies - emphasize the word-by-word processing of sentences. This paradigm is good for approximating speech or careful text reading, but arguably, not for the common, cursory glances used while reading short sentences (e.g.

Supporting contraceptive self-care and reproductive empowerment with a digital health game in Barbados: Development and Pre-implementation study for What's My Method?

Effective contraceptive education is essential to reducing unwanted pregnancy, increasing uptake of modern contraceptive methods, and thoughtfully planning desired births. New World Health Organization (WHO) and family planning organization guidelines recommend situating contraceptive education and counseling within a broader context of self-care that emphasizes individual agency and reproductive empowerment. Digital health interventions, and games for health specifically, have been validated as effective and scalable tools for self-guided and interactive health education, especially among younger tech-savvy individuals.

A Further Look at Perception of Personalities in Typefaces: Evidence From Turkish.

Previous research conducted in English indicates that the visual appearances of different typefaces are perceived as possessing distinct characteristics, what we call "print personality" (e.g., masculine, feminine, serious, fun) to the extent that the typeface used conveys information to the reader beyond that which is expressed linguistically by the word.

Social, Emotional, and Behavioral Functioning in Adolescents with Klinefelter Syndrome.

Objective: Klinefelter syndrome (KS) is a common genetic condition in males associated with an extra X chromosome (i.e., 47,XXY).

Slip Flow in Hydrophilic Nanopores of Silica Colloidal Crystals.

Slip flow, a fluid flow enhanced in comparison to that calculated using continuum equations, has been reported for many nanopores, mostly those with hydrophobic surfaces. We investigated the flow of water, hexane, and methanol through hydrophilic nanopores in silica colloidal crystals. Three silica sphere sizes were used to prepare the crystals: 150 ± 30, 500 ± 40, and 1500 ± 100 nm.

Connectivity in the Dorsal Visual Stream Is Enhanced in Action Video Game Players.

Action video games foster competitive environments that demand rapid spatial navigation and decision-making. Action video gamers often exhibit faster response times and slightly improved accuracy in vision-based sensorimotor tasks. However, the underlying functional and structural changes in the two visual streams of the brain that may be contributing to these cognitive improvements have been unclear.

Rebuilding the clinical and operational acute care pharmacist productivity model: Leveraging electronic health record data and analytics at an academic medical center.

Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Pharmacist preceptor perceptions of diversity, equity, and inclusion in experiential learning experiences.

Introduction: Societal inequities and public discourse have prompted healthcare organizations to focus on Diversity, Equity, and Inclusion (DEI). While DEI initiatives and strategic plans have been established within academia and applied to didactic curricula, literature is limited on preceptor perspectives in engagement with DEI. This study aimed to assess pharmacist preceptor perception of DEI in learning experiences and areas for improvement in the context of experiential teaching and learning within a large, multi-site pharmacy residency program to provide guidance for strategies to improve organizational approaches.

Canine and Feline Pemphigus Foliaceus-an Update on Pathogenesis and Treatment.

Pemphigus foliaceus (PF) is one of the most common autoimmune skin diseases of dogs and cats and is characterized by the development of pustules, crusts, erosions, scales, and alopecia. Albeit poorly understood, the pathophysiology of canine and feline PF appears to involve immune dysregulation and immunoglobulin G autoantibodies that are directed against the keratinocyte cell surface. At present, the management of canine and feline PF relies on the long-term to lifelong prescription of immunosuppressive medications.

Neuroanatomical alterations in young boys and adolescents with Klinefelter syndrome.

Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males that is characterized by pubertal developmental delays and a wide range of alterations in cognitive, social and emotional functioning. The neural bases of these behavioral symptoms, however, are unclear. A total of 130 boys and adolescents, including 67 males with KS (11.

The Natural Products Magnetic Resonance Database (NP-MRD) for 2025.

The Natural Products Magnetic Resonance Database (NP-MRD; https://np-mrd.org) is a comprehensive, freely accessible, web-based resource for the deposition, distribution, extraction, and retrieval of nuclear magnetic resonance (NMR) data on natural products (NPs). The NP-MRD was initially established to support compound de-replication and data dissemination for the NP community.

Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns.

Cell-cell communication through direct contact, or juxtacrine signaling, is important in development, disease, and many areas of physiology. Synthetic forms of juxtacrine signaling can be precisely controlled and operate orthogonally to native processes, making them a powerful reductionist tool with which to address fundamental questions in cell-cell communication in vivo. Here, we investigate how cell-cell contact length and tissue growth dynamics affect juxtacrine signal responses through implementing a custom synthetic gene circuit in Drosophila wing imaginal discs alongside mathematical modeling to determine synthetic Notch (synNotch) activation patterns.

The Reicher-Wheeler paradigm in word recognition research: a cautionary note on its actual contributions and published misconceptions.

The study of word recognition has been influenced greatly by findings obtained when visual stimuli are presented very briefly. Under these conditions, a great deal of evidence suggests that words are perceived better than nonwords, and even single letters, and it is generally accepted that these "word superiority effects" reflect the relative efficiency with which words are perceived. For more than 50 years, a key procedure for establishing these effects has been the Reicher-Wheeler Paradigm in which potentially confounding effects of non-perceptual guesswork are cleverly suppressed.

Effects of oral contraceptive pills on brain networks: A replication and extension.

Neuroimaging research has identified significant effects of oral contraceptive pills (OCPs) on brain networks. A wide variety of approaches have been employed, largely in observational samples, with few converging results. This study therefore was designed to test for replication and extend this previous work using a randomized, double-blind, placebo-controlled crossover trial of the effects of OCPs on brain networks.

Stimulating the posterior parietal cortex reduces self-reported risk-taking propensity in people with tobacco use disorder.

Previous research has identified a replicable role for the posterior parietal cortex (PPC) in risk behaviors, but it is unclear whether this relationship is causal. Here, we used a targeted neuromodulation protocol leveraging a single-session of 10-Hz rTMS to the PPC versus a control region in the visual cortex (V5), as well as two active comparison regions [superior frontal gyrus (SFG), dorsolateral prefrontal cortex (DLPFC)] (within-person, randomized order), to examine within-session changes in a comprehensive measure of self-reported risk-taking propensity (the Domain-Specific Risk-Taking or DOSPERT scale). Individuals with tobacco use disorder were selected as sample participants who present with clinically relevant risk-taking propensity ( = 50; 14 women, mean [] age=33.

Alterations in cortical and subcortical neuroanatomy and associations with behavior in females with fragile X syndrome.

Aim: To address substantial gaps in the literature on neuroanatomical variations in females with fragile X syndrome (FXS).

Method: Surface-based modeling techniques were applied to the magnetic resonance imaging of 45 females with FXS (mean age = 10 years 9 months, range 6 years-16 years 4 months, SD = 2 years 9 months) and 33 age-matched and developmentally matched females without FXS to elucidate differences in cortical gray matter volume, surface area, and thickness. Gray matter volumes in subcortical regions were examined to ascertain differences in subcortical volume.

Cognitive and Social-Emotional Development in Girls With Fragile X Syndrome.

Objectives: To evaluate the developmental trajectory of key cognitive, social, and emotional features in girls with fragile X syndrome (FXS).

Methods: This longitudinal, parallel cohort study collected data between January 2018 and December 2022. Participants were evaluated 3 times with ∼12-18 months between visits.

An in vivo screen for proteolytic switch domains that can mediate Notch activation by force.

Unlabelled: Notch proteins are single pass transmembrane receptors activated by sequential extracellular and intramembrane cleavages that release their cytosolic domains to function as transcription factors in the nucleus. Upon binding, Delta/Serrate/LAG-2 (DSL) ligands activate Notch by exerting a "pulling" force across the intercellular ligand/receptor bridge. This pulling force is generated by Epsin-mediated endocytosis of ligand into the signal-sending cell, and results in the extracellular cleavage of the force-sensing Negative Regulatory Region (NRR) of the receptor by an ADAM10 protease [Kuzbanian (Kuz) in ].

Associations between brain network, puberty, and behaviors in boys with Klinefelter syndrome.

Background: Klinefelter syndrome (KS), also referred to as XXY syndrome, is a significant but inadequately studied risk factor for neuropsychiatric disability. Whether alterations in functional brain connectivity or pubertal delays are associated with aberrant cognitive-behavioral outcomes in individuals with KS is largely unknown. In this observational study, we investigated KS-related alterations in the resting-state brain network, testosterone level, and cognitive-behavioral impairment in adolescents with Klinefelter syndrome.

Revealing a word superiority effect using a unique variant of the Latin alphabet: the evidence from Turkish.

When visual stimuli are presented briefly, words are perceived better than nonwords. It is widely accepted that this word superiority effect reflects the efficiency with which words are perceived. However, most of what is known about the effect comes from languages (like English) using the basic Latin alphabet and little is known about whether languages using an alphabetic variant with very different properties can also produce word superiority.

A study demonstrating users' preference for the adapted-REQUITE patient-reported outcome questionnaire over PRO-CTCAE in patients with lung cancer.

Introduction: The use of patient-reported outcomes (PROs) has been shown to enhance the accuracy of symptom collection and improve overall survival and quality of life. This is the first study comparing concordance and patient preference for two PRO tools: Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) and the adapted-REQUITE Lung Questionnaire.

Materials And Methods: Patients with lung cancer were recruited to the study while attending outpatient clinics at a tertiary cancer centre.

Stem cell engineering approaches for investigating glial cues in central nervous system disorders.

Glial cells are important in maintaining homeostasis for neurons in the central nervous system (CNS). During CNS disease or after injury, glia react to altered microenvironments and often acquire altered functions that contribute to disease pathology. A major focus for research is utilizing stem cell (SC)-derived glia as a potential renewable source for cell replacement to restore function, including neuronal support, and as a model for disease states to identify therapeutic targets.