Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic Strain KCh KW1.1.

Progesterone biotransformation is worth studying because of the high industrial value of its derivatives. This study investigated the catalytic ability of the entomopathogenic filamentous fungus strain KCh KW1.1 to transform progesterone derivatives: 11α-hydroxyprogesterone, 17α-hydroxyprogesterone, 16α,17α-epoxyprogesterone and pregnenolone.

Biological Potential and Chemical Profile of European Varieties of .

Plants of the genus are widespread throughout the world, with its best-known representative being from South America. The European species shows similarities in its terpenoid, sugar and phenolic acid profiles. Using aqueous extracts of as a supplement in Wistar rats showed that, despite the lack of caffeine, it had strong hypocholesterolemic effects.

Metallacarborane Derivatives Effective against and .

is an opportunistic human pathogen that has become a nosocomial health problem worldwide. The pathogen has multiple drug removal and virulence secretion systems, is resistant to many antibiotics, and there is no commercial vaccine against it. is a zoonotic pathogen that is on the Select Agents list.

New 6,19-oxidoandrostan derivatives obtained by biotransformation in environmental filamentous fungi cultures.

Background: Steroid compounds with a 6,19-oxirane bridge possess interesting biological activities including anticonvulsant and analgesic properties, bacteriostatic activity against Gram-positive bacteria and selective anti-glucocorticoid action, while lacking mineralocorticoid and progestagen activity.

Results: The study aimed to obtain new derivatives of 3β-acetyloxy-5α-chloro-6,19-oxidoandrostan-17-one by microbial transformation. Twelve filamentous fungal strains were used as catalysts, including entomopathogenic strains with specific activity in the transformation of steroid compounds.

Identification of a potent inhibitor of type II secretion system from Pseudomonas aeruginosa.

Pseudomonas aeruginosa is an opportunistic pathogen infecting human population. The pathogen is becoming a serious health problem due to its ability to evade normal immune response of the host and multiple drug resistance to many antibiotics. The pathogen has 2 major virulence systems of which the type III secretion system (T3SS) is of major concern to humans.

Biotransformation of steroids by entomopathogenic strains of Isaria farinosa.

Background: Steroid compounds are very interesting substrates for biotransformation due to their high biological activity and a high number of inactivated carbons which make chemical modification difficult. Microbial transformation can involve reactions which are complicated and uneconomical in chemical synthesis, and searching for a new effective biocatalyst is necessary. The best known entomopathogenic species used in steroid modification is Beauveria bassiana.