Antimicrobial activity of a natural compound and analogs against multi-drug-resistant Gram-positive pathogens.

Unlabelled: The increasing prevalence of methicillin-resistant (MRSA) has sparked global concern due to the dwindling availability of effective antibiotics. To increase our treatment options, researchers have investigated naturally occurring antimicrobial compounds and have identified MC21-A (C58), which has potent antimicrobial activity against MRSA. Recently, we have devised total synthesis schemes for C58 and its chloro-analog, C59.