Publications by authors named "Jordan Said"

Background: There are no validated methods to identify individuals with cutaneous lupus erythematosus (CLE) from large databases including claims data and electronic health records, severely limiting the study of the epidemiology of this disease.

Objectives: To develop and validate accurate algorithms to identify individuals with CLE from healthcare records.

Methods: Twelve case-finding algorithms were developed based on the International Classification of Diseases (ICD)-10 diagnosis codes, provider specialty, and medication prescription data.

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  • Folliculosebaceous cystic hamartoma (FSCH) is a rare skin growth that contains both epithelial and mesenchymal tissue, usually presenting as a slow-growing, skin-colored nodule on the face or scalp.
  • A case is highlighted involving a 45-year-old male with a 4 mm nodule on his temple, which was initially misidentified as an epidermal inclusion cyst (EIC), but further examination confirmed it was FSCH due to its unique structure.
  • The standard treatment for FSCH is surgical excision, and post-surgery, the patient has not experienced any recurrence, emphasizing the need to distinguish FSCH from EIC in similar cases.
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Introduction: Cutaneous adverse reactions to epidermal growth factor receptor inhibitors (EGFRi) are some of the most common side effects that patients experience. However, cutaneous adverse reactions that cause dyspigmentation in patients have been rarely reported. Erythema dyschromicum perstans (EDP) is a rare pigmentary condition that causes ashy-grey hyperpigmented macules and patches, with a few cases reported from EGFRi in the literature.

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The early phase of the COVID-19 pandemic prompted a repurposing of antiviral and immunomodulatory drugs as investigational therapeutics, including hydroxychloroquine and chloroquine. While antimalarials have been well-refuted as a treatment for COVID-19, data on these drugs' role in preventing SARS-CoV-2 infection as pre-exposure prophylaxis is more limited. We investigated the efficacy of antimalarial drugs as pre-exposure SARS-CoV-2 prophylaxis in a US tertiary-care center.

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  • Mogamulizumab is increasingly used to treat T-cell lymphomas, and a study was done to find immune-related muscle issues caused by this medication in patients at Dana-Farber Cancer Institute.
  • The study found 5 out of 42 patients (11.9%) experienced muscle-related adverse events, including myositis and myocarditis, with some cases also linked to myasthenia gravis.
  • The side effects can develop late, sometimes up to 100 days after the last treatment, and the study suggests using IVIG and corticosteroids for effective management of these serious complications.
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Background: Cutaneous immune-related adverse events (irAEs) are the most common irAEs caused by immune-checkpoint inhibitors (ICI). Psoriasiform eruptions, both and flares, may occur. Evidence is lacking on inverse psoriasis subtype.

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  • Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare, benign skin condition with a good prognosis, but its features and treatments are not well understood.
  • A study found that most patients achieved complete remission after various treatments including biopsies, corticosteroids, and radiation.
  • The majority of patients responded positively to localized therapies, with very few cases progressing beyond the skin, highlighting the effectiveness of targeted treatment strategies.*
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  • Supportive oncodermatology enhances patient care, particularly in diagnosing skin toxicities from immune checkpoint inhibitors (ICIs), yet research highlighting its diagnostic accuracy is limited.
  • A study analyzed patient data to compare diagnosis accuracy between general dermatologists and supportive oncodermatologists using skin biopsy results for immune-related adverse events (cirAEs) linked to cancer treatments.
  • Results showed that supportive oncodermatologists had significantly lower rates of initial misdiagnosis (27.3%) compared to general dermatologists (55.3%), suggesting their expertise may improve diagnostic outcomes in cancer-related skin issues.
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Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare benign lymphoproliferative disorder, recently redefined by the 2016 World Health Organization classification of lymphoid neoplasms. In adults, PCSM-TCLPD responds well to monotherapy with surgical excision or local radiation, with or without topical/injected corticosteroids; in contrast, PCSM-TCLPD has only rarely been reported in children, in whom treatments favored in adults may be non-optimal. We present a 14-year-old male with PCSM-TCLPD on the forehead, who achieved complete remission following biopsy, topical corticosteroids, and surgical excision.

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This cohort study assesses the outcomes of acitretin treatment for multikinase inhibitor–associated hand-foot skin reaction.

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  • De novo bullous pemphigoid (BP) is a rare but serious skin condition that can develop in patients receiving immune checkpoint inhibitors (ICIs) for cancer treatment, potentially leading to the need for stopping the therapy permanently.
  • A study was conducted to identify risk factors for developing BP by comparing patients who experienced this condition after ICI treatment with those who did not, using data from major hospitals over a six-year period.
  • The analysis examined various factors, including demographics and medical history, to assess their relationship to BP development, with the ultimate goal of improving patient care and treatment strategies in oncology.
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Purpose: Existing frameworks to address instances of microaggressions and discrimination in the clinical environment have largely been developed for faculty and resident physicians, creating a lack of resources for medical students.

Methods: We implemented a workshop to prepare pre-clinical medical/dental students to recognize and respond to microaggressions. Participants in three cohorts from 2018 to 2020 completed pre- and post-workshop surveys assessing the prevalence of exposure to clinical microaggressions and the workshop's effect on mitigating commonly perceived barriers to addressing microaggressions.

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Background: Elective introductory clerkships in dermatology serve a critical function in providing formative experiences to medical students interested in the field. Although dermatology clerkships play a pivotal role in students' career choices and residency preparation, the assessment systems used to evaluate students on these clerkships are widely different and likely affect student experiences.

Objective: This study aimed to explore the relationship between dermatology clerkship assessment systems and student experiences through interviews with students about their clerkship reflections and perceptions of assessment.

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  • Due to supply shortages from the COVID-19 pandemic, N95 masks, which are usually single-use, have been used for extended periods, leading to issues with fit and effectiveness, prompting research into a solution to improve their reusability.
  • The study created a 3D printed mask frame using common materials, which helped to enhance the fit of damaged or poorly fitting N95 and KN95 masks during testing, allowing more users to achieve a proper seal.
  • Findings showed that nearly 73% of participants could obtain a good fit using the frames, which could provide a cost-effective way to extend the usability of masks without compromising their protective capabilities.
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Objective: Case-based collaborative learning (CBCL) models that incorporate learner-guided content review, structured preparatory assessment, and interactive case-based classroom sessions have been shown to promote content mastery among medical students. However, limited research has explored the viability of CBCL in resident populations, particularly in dermatology. We therefore sought to investigate the impact of a CBCL curriculum covering complex medical dermatology topics on resident knowledge and learning preferences.

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