Publications by authors named "Jordan R Hoffman"

Article Synopsis
  • The text discusses the challenges and potential of using organs from donors who die after cardiac arrest (DCD), highlighting that while there’s a significant need for donor organs, the outcomes for these organs have been historically poor.
  • Normothermic regional perfusion (NRP) is introduced as a technique that can enhance the outcomes and increase the use of DCD organs, but there is inconsistency in how different US organ procurement organizations (OPOs) implement it.
  • A survey of 55 OPOs revealed variations in NRP practices, with 49 OPOs having conducted NRP cases; most respondents expressed a need for standardized guidelines to improve the consistency and effectiveness of NRP procedures.
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Noteworthy in Cardiothoracic Surgery 2023 summarizes a few of the most high-impact trials and provocative trends in cardiothoracic surgery and transplantation this past year. Transplantation using organs procured from donation after circulatory death (DCD) continues to increase, and the American Society of Transplant Surgeons released recommendations on best practices in 2023. We review a summary of data on the impact of DCD on heart and lung transplantation.

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Article Synopsis
  • This study investigates how travel time to heart transplantation centers affects healthcare accessibility and survival outcomes for patients.
  • It analyzed over 25,000 adult heart transplant recipients in the U.S. from 2012 to 2022, revealing that longer travel times were linked to poorer long-term survival, especially for white recipients.
  • The findings indicate that addressing long travel times could enhance healthcare accessibility and improve survival rates among heart transplant patients.
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Variation in mitochondrial genome composition across intraspecific, interspecific, and higher taxonomic scales has been little studied in lichen obligate symbioses. is one of the most diverse and ecologically important lichen genera, with over 500 species representing an array of unique morphologies and chemical profiles. Here, we assess mitochondrial genome diversity and variation in this flagship genus, with focused sampling of two clades of the "true" reindeer lichens, subgenus , and additional genomes from nine outgroup taxa.

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Lichenized fungi are known for their production of a diversity of secondary metabolites, many of which have broad biological and pharmacological applications. By far the most well-studied of these metabolites is usnic acid. While this metabolite has been well-known and researched for decades, the gene cluster responsible for its production was only recently identified from the species Cladonia uncialis.

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DNMT3B is known as a de novo DNA methyltransferase. However, its preferential target sites for DNA methylation are largely unknown. Our analysis on ChIP-seq experiment in human embryonic stem cells (hESC) revealed that DNMT3B, mCA and H3K36me3 share the same genomic distribution profile.

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Population genetic analyses of species inhabiting fragmented landscapes are essential tools for conservation. Occasionally, analyses of fragmented populations find no evidence of isolation, even though a barrier to dispersal is apparent. In some cases, not enough time may have passed to observe divergence due to genetic drift, a problem particularly relevant for long-lived species with overlapping generations.

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Patients with blunt aortic injury often present to the emergency department in a relatively hypovolemic state. These patients undergo extensive inhospital resuscitation. The effect of posttraumatic resuscitation on aortic diameter has implications for stent graft sizing.

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The impact on outcomes resulting from crystalloids used with hemostatic close ratio resuscitation (HCRR) in intraoperative hemorrhage (IOH) has not been analyzed. We hypothesize a survival advantage in patients with IOH managed with a low-volume resuscitation (LVR) protocol during HCRR. A 4-year case-control study was conducted to determine the impact on mortality of LVR versus conventional resuscitation efforts (CRE) during HCRR.

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