Inflammatory Cytokines Associate With Neuroimaging After Acute Mild Traumatic Brain Injury.

Elevated levels of blood-based proinflammatory cytokines are linked to acute moderate to severe traumatic brain injuries (TBIs), yet less is known in acute mild (m)TBI cohorts. The current study examined whether blood-based cytokines can differentiate patients with mTBI, with and without neuroimaging findings (CT and MRI). Within 24 h of a mTBI, determined by a Glasgow Coma Scale (GCS) between 13 and 15, participants ( = 250) underwent a computed tomography (CT) and magnetic resonance imaging (MRI) scan and provided a blood sample.

Elevated Tau in Military Personnel Relates to Chronic Symptoms Following Traumatic Brain Injury.

Objective: To understand the relationships between traumatic brain injury (TBI), blood biomarkers, and symptoms of posttraumatic stress disorder (PTSD), depression, and postconcussive syndrome symptoms.

Design: Cross-sectional cohort study using multivariate analyses.

Participants: One hundred nine military personnel and veterans, both with and without a history of TBI.