Publications by authors named "Jordan M Wall"
Article Synopsis
- Dopaminergic neurons are particularly vulnerable to trauma-induced neurodegeneration, a trait observed in various species from nematodes to humans.
- The research highlights that dopamine, which plays a crucial role in Parkinson's disease, becomes toxic during injuries, especially when produced outside its usual neurons.
- An imbalance in dopamine levels due to trauma leads to cell damage, and this vulnerability is intensified by an increase in a key enzyme for dopamine production triggered by the FOS-1 transcription factor.
Cells sense stress and initiate response pathways to maintain lipid and protein homeostasis. However, the interplay between these adaptive mechanisms is unclear. Herein, we demonstrate how imbalances in cytosolic protein homeostasis affect intracellular lipid surveillance.
View Article and Find Full Text PDFMutations in Valosin Containing Protein (VCP) are associated with several degenerative diseases, including multisystem proteinopathy (MSP-1) and amyotrophic lateral sclerosis. However, patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise effective treatment strategies. A deeper understanding of how each mutation affects VCP function could enhance the prediction of clinical outcomes and design of personalized treatment options.
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