Retinal fluid quantification using a novel deep learning algorithm in patients treated with faricimab in the TRUCKEE study.

Background: Investigate retinal fluid changes via a novel deep-learning algorithm in real-world patients receiving faricimab for the treatment of neovascular age-related macular degeneration (nAMD).

Methods: Multicenter, retrospective chart review and optical coherence tomography (OCT) image upload from participating sites was conducted on patients treated with faricimab for nAMD from February 2022 to January 2024. The Notal OCT Analyzer (NOA) algorithm provided intraretinal, subretinal and total retinal fluid for each scan.

Interim Results of the Phase III Portal Extension Trial of the Port Delivery System with Ranibizumab in Neovascular Age-Related Macular Degeneration.

Objective: The Port Delivery System with ranibizumab (PDS) is approved in the United States for neovascular age-related macular degeneration (nAMD). Portal (NCT03683251) is evaluating long-term safety and tolerability of the PDS in patients with nAMD who completed the phase II Ladder (NCT02510794) or phase III Archway (NCT03677934) trials.

Design: Multicenter, nonrandomized, open-label, extension clinical trial.

Exudation in Patients With Neovascular Age-Related Macular Degeneration Treated With the Port Delivery System or Monthly Injections.

Purpose: To evaluate for the presence, severity, and type of exudation at each study visit for a subgroup of patients with neovascular age-related macular degeneration from the Archway and Portal trials.

Design: Retrospective analysis of prospectively obtained data.

Methods: Spectral-domain optical coherence tomography scans from each study visit of 44 patients from the Port Delivery System (PDS) arm and 32 patients from the monthly injection arm of Archway were evaluated, and composites of horizontal scans through the fovea were created.

Refill-Exchange Procedure of the Port Delivery System With Ranibizumab: Overview and Clinical Trial Experience.

Purpose: To describe the Port Delivery System with ranibizumab refill-exchange procedure.

Methods: Procedure based on the clinical trial program in patients with retinal diseases.

Results: The refill-exchange procedure is performed under topical anesthesia and strict aseptic conditions.

Conjunctiva and Tenon's Capsule Handling in the Port Delivery System with Ranibizumab Implant Insertion Procedure: Surgical Pearls.

Objectives: To describe conjunctiva and Tenon's capsule handling during the Port Delivery System with ranibizumab (PDS) implant insertion procedure including up-front assessments, planning, and instrumentation, with emphasis placed on the peritomy, scleral dissection, and closure steps.

Methods: Surgical pearls based on experience accumulated in the PDS clinical trial program in patients with retinal diseases.

Results: Preoperative preparation, specific instruments, and meticulous techniques are key to optimizing surgical outcomes.

Intraoperative sclerotomy-related retinal breaks during 23-gauge pars plana vitrectomy.

Purpose: To study the incidence and characteristics of intraoperative sclerotomy-related retinal breaks encountered during 23-gauge pars plana vitrectomy.

Methods: A retrospective consecutive case series was assembled from the surgical logs and charts of patients who underwent 23-gauge pars plana vitrectomy. Demographic data and preoperative, intraoperative, and postoperative records were examined.

Temporal approach for small-gauge pars plana vitrectomy combined with anterior segment surgery.

Purpose: To describe our preliminary experience with temporal small-gauge pars plana vitrectomy (PPV) techniques used to treat anterior and posterior segment pathology.

Methods: A retrospective consecutive case review of patients who underwent temporal PPV was performed. Patients underwent combined temporal small-gauge PPV and anterior segment intervention.

Sutureless triplanar sclerotomy for 23-gauge vitrectomy.

Objectives: To describe and test the intraoperative integrity of triplanar sclerotomies.

Methods: A prospective consecutive case series of 180 sclerotomies in 60 eyes was studied. After conjunctival dissection, triplanar transscleral wounds were created with a 23-gauge trocar using a standardized technique.

Fluoroquinolone therapy in Mycobacterium chelonae keratitis after lamellar keratectomy.

Purpose: To characterize a rabbit model of Mycobacterium chelonae keratitis after lamellar keratectomy and assess the effectiveness of fluoroquinolone therapy.

Setting: University Laboratory, University of California, Irvine, California, USA.

Methods: Twenty-eight New Zealand white rabbits had unilateral lamellar keratectomy with placement of 2.

In vitro measurement of rabbit corneal epithelial thickness using ultrahigh resolution optical coherence tomography.

The objective of this study was to reproducibly measure corneal epithelial thickness centrally and at the limbus in the rabbit cornea using ultrahigh resolution optical coherence tomography (OCT). Twelve freshly enucleated New Zealand white rabbit eyes were kept in a moist chamber at 4 degrees C. An ultrahigh resolution OCT system with a spatial resolution of 1.

Biomechanical characterization of human amniotic membrane preparations for ocular surface reconstruction.

Purpose: To investigate the tensile and elastic properties of both commercially available and experimental human amniotic membrane preparations.

Method: Nine preparations of human amniotic membrane were studied. The four dry preparations were untreated (nonirradiated, n = 20), and gamma (n = 25), low-dose (AmbioDry, Okto Ophtho Inc.

A rat model of radiofrequency ablation of trigeminal innervation via a ventral approach with stereotaxic surgery.

Neurotrophic keratopathy (NK), a consequence of sensory denervation of the cornea, must be better understood in order to develop new approaches to therapy. The purpose of this study was to create a rat model for neurotrophic keratopathy by denervating the trigeminal nerve through a ventral approach with stereotaxic surgery. Stereotaxic coordinates were measured in 46 male Sprague Dawley rat cadavers for localization of V1.