Publications by authors named "Jordan K Towne"
Article Synopsis
- ZO-1 is a crucial protein that regulates cell signaling and communication, but its specific role in cardiac myocytes (CM) was previously unclear.
- The study created a specific knockout model of ZO-1 in mice (ZO-1cKO) to investigate its impact on heart function and structure.
- Results showed that while the overall heart structure remained normal, ZO-1cKO mice exhibited significant electrical conduction issues, particularly high-grade atrioventricular block, suggesting that ZO-1 plays an essential role in cardiac electrical signaling.
