Publications by authors named "Jordan E Searle"
Article Synopsis
- The membrane potential in nonexcitable cells is crucial for cell health, affecting ionic currents and playing roles in cellular functions like differentiation and signaling.
- Research on trabecular meshwork (TM) cells reveals a significant cationic conductance that maintains their resting potential, which is not mediated by common ion channels typically associated with such currents.
- The identified conductance likely involves TRP-like channels and could impact intraocular pressure regulation in both healthy and diseased eyes by influencing outflow and response to pressure changes.
Ocular hypertension (OHT) caused by mechanical stress and chronic glucocorticoid exposure reduces the hydraulic permeability of the conventional outflow pathway. It increases the risk for irreversible vision loss, yet healthy individuals experience nightly intraocular pressure (IOP) elevations without adverse lifetime effects. It is not known which pressure sensors regulate physiological vs.
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