Considerations Using Harmaline for a Primate Model of Tremor.

Background: While harmaline has been used as a pharmacological model of essential tremor (ET) in rodents and pigs, less is known about the effects of this pharmacological treatment in awake-behaving non-human primates. In this study, we investigated the time-course, amplitude, frequency, and consistency of harmaline tremor in primates.

Methods: Three rhesus macaques were administered doses of harmaline ranging from 2-12 mg/kg (i.