Menthol blunts the interoceptive discriminative stimulus effects of nicotine in female but not male rats.

Rationale: Menthol is a widely used tobacco constituent that has shown to enhance nicotine's reinforcing effects.

Objective: To determine whether injected menthol also alters nicotine's stimulus effects, we used a drug discrimination task.

Methods: A total of 57 adult Sprague-Dawley rats (28M, 29F) received 20 positive and 20 negative days (intermixed) of discrimination training.