Publications by authors named "Jordan Chin"
Article Synopsis
- Mitochondrial metabolite hexokinase 2 (HK2) is found in the nucleus of both leukaemic and normal haematopoietic stem cells, affecting their functions.
- Overexpressing HK2 in the nucleus enhances leukaemic stem cell traits and inhibits differentiation, while reducing HK2 promotes differentiation and reduces stem cell properties.
- HK2's nuclear presence relies on phosphorylation and specific transport mechanisms, impacting DNA repair and chemoresistance without its enzymatic function, highlighting a novel role for mitochondrial enzymes in regulating stem cells.
