The α-dystrobrevins play a key role in maintaining the structure and function of the extracellular matrix-significance for protein elimination failure arteriopathies.

The extracellular matrix (ECM) of the cerebral vasculature provides a pathway for the flow of interstitial fluid (ISF) and solutes out of the brain by intramural periarterial drainage (IPAD). Failure of IPAD leads to protein elimination failure arteriopathies such as cerebral amyloid angiopathy (CAA). The ECM consists of a complex network of glycoproteins and proteoglycans that form distinct basement membranes (BM) around different vascular cell types.

Effects of Time-of-Day Training Preference on Resistance-Exercise Performance.

The purpose of this study was to investigate how time-of-day training preference influences resistance-exercise performance. Resistance trained males ( = 12) were recruited for this study. In a crossover, counterbalanced design, participants completed two separate bench-press exercise trials at different times of day: (a) morning (AM; 8:00 hr) and (b) evening (PM; 16:00 hr).